Neutralization Mechanisms Of Anti-HIV-1 Monoclonal Antib

抗 HIV-1 单克隆抗体的中和机制

• 批准号: 7174923
• 负责人: Peter D Kwong
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7174923
• 关键词: CD4 molecule; HIV envelope protein gp120; SDS polyacrylamide gel electrophoresis; X ray crystallography; antigen antibody reaction; autoradiography; binding sites; cytokine receptors; enzyme linked immunosorbent assay; epitope mapping; flow cytometry; human immunodeficiency virus 1; human tissue; monoclonal antibody; neutralizing antibody; protein structure; protein structure function

A lack of neutralizing antibodies distinguishes HIV-1 from most other viral pathogens and is responsible to a large degree for the ability of HIV-1 to maintain a persistent infection. A few monoclonal antibodies have been isolated that are broadly neutralizing. We investigate the epitopes of these and their mechanisms of neutralization.

HIV-1 与大多数其他病毒病原体的区别在于缺乏中和抗体，并且在很大程度上导致了 HIV-1 维持持续感染的能力。已经分离出一些具有广泛中和作用的单克隆抗体。我们研究了这些表位及其中和机制。