Design Of Immunogens

免疫原的设计

• 批准号: 7299829
• 负责人: Peter D Kwong
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7299829
• 关键词: Design; Immunogens

Based on our understanding of envelope-based mechanisms of humoral evasion, we have attempted to design envelope-based immunogens with these mechanisms disabled. Such modied immunogens with weakened defenses may elicit more broadly neutralizing antibodies. We have also devised scaffolding technology, as a means of presenting structural mimics of the epitopes of broadly neutralizing antibodies to assist in their re-elicitation.

基于我们对基于信封的逃避机制的理解，我们试图使用这些机制来设计基于信封的免疫原理。这种修饰的防御能力减弱的免疫原子可能会引起更广泛的中和抗体。我们还设计了脚手架技术，是展示广泛中和抗体的表位的结构模拟方法，以帮助其重新启动。