Mechanisms Of Humoral Evasion

体液逃避的机制

• 批准号: 8745617
• 负责人: Peter D Kwong
• 金额: $ 83.55万
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8745617
• 关键词: Antibodies; Glycoproteins; Goals; HIV-1; Immune; Immune response; Infection; Learning; Licensing; Masks; Methods; Palivizumab; Polysaccharides; Respiratory syncytial virus; Structure; Time; Vaccine Design; Vaccines; Virus; base; design; neutralizing antibody; prophylactic; response

The HIV-1 envelope contains multiply overlapping (and redundant) mechanisms of humoral immune defence. These including glycan shielding, conformational masking, and immunodominant decoys with variable loops. Although explored extensively, many of these mechanisms are still only partially understood. We are using structure-based methods to define them further. In addition, we are examining the fusion glycoprotein from respiratory syncytial virus, to understand its mechanisms of humoral evasion.

HIV-1 包膜包含多种重叠（和冗余）的体液免疫防御机制。 这些包括聚糖屏蔽、构象掩蔽和具有可变环的免疫显性诱饵。 尽管进行了广泛的探索，但其中许多机制仍然只有部分被了解。 我们正在使用基于结构的方法来进一步定义它们。 此外，我们正在研究呼吸道合胞病毒的融合糖蛋白，以了解其体液逃逸的机制。