3D bioprinted hydrogel models for the study and treatment of human liver disease

用于研究和治疗人类肝脏疾病的 3D 生物打印水凝胶模型

• 批准号: 2879464
• 金额: --
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2879464
• 关键词: 3D; bioprinted; hydrogel; models; study

Fully-funded PhD studentship on 3D bioprinted vascular branches reinforced with nanofibre mesh. This is a standard 3.5-year UK PhD. The lack of vascularization is the main bottleneck of bioprinting functional organs. This project aims at developing a vascular tree consisting of arteries, veins, and ureter, for artificial kidney development. The student will learn how to operate our novel home-built hybrid 3D bioprinter, which combines hydrogel printing with electrospinning. The student will make polymeric solutions for electrospinning and for bioprinting hydrogels, and work with cell cultures. The generated hybrid structures will be characterized by microscopy techniques (SEM, confocal laser scanning microscopy, fluorescence microscopy, etc.) and by assessing the mechanical performance. Within the project the student will use state-of-the-art characterization techniques. Half of the work will be carried out at the Swiss Federal Laboratories for Materials Science and Technology (Empa) in St. Gallen, Switzerland, a material research institute belonging to the ETH domain (Swiss Federal Institute of Technology).

3D生物打印的血管分支的全资金学生资助的学生身份加强了纳米纤维网。这是标准的3。5年英国博士。缺乏血管形成是生物打印功能器官的主要瓶颈。该项目旨在开发一种由动脉，静脉和输尿管组成的血管树，用于人造肾脏发育。学生将学习如何操作我们新颖的家庭建造混合动力3D Bioprointer，该混合动力3D BioProinter将水凝胶印刷与电纺丝结合在一起。该学生将制造用于静电纺丝和生物打印水凝胶的聚合物溶液，并与细胞培养物一起使用。生成的杂种结构将以显微镜技术（SEM，共聚焦激光扫描显微镜，荧光显微镜等）以及评估机械性能进行特征。在项目中，学生将使用最先进的特征技术。一半的工作将在瑞士圣加伦的瑞士联邦材料科学技术实验室（EMPA）进行，这是一家属于ETH Domain（瑞士联邦技术研究所）的材料研究所。