CORE--DATA MANAGEMENT AND BIOSTATISTICS

核心——数据管理和生物统计学

• 批准号: 6932657
• 负责人: ELLEN M WIJSMAN
• 金额: $ 20.46万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6932657
• 关键词: Alzheimer' s disease; biomedical facility; computational biology; data management; experimental designs; genetics; statistics /biometry

The primary objective of this Core is to provide data management, statistical genetic, and biostatistical support to the Cores and Projects of the University of Washington Alzheimer's Disease Research Center (ADRC). Our specific aims are: (1) To provide database management support to projects, cores and pilot projects;(2) To provide support to projects, cores and pilot projects in the areas of statistical and statistical genetic design and analysis at the UW ADRC and at other ADCs; (3) To assist projects, cores, and pilot projects in manuscript preparation relating to statistical and statistical genetic analyses; (4) To maintain a proactive approach to provision of such support; and (5) To evaluate, develop, extend, and apply appropriate statistical and statistical genetic methodologies for problems arising out of projects, cores, and pilot projects. Core computer specialists construct, modify, and maintain the databases needed to store and access the ADRC data for the analytical needs of the cores and projects, and to be able to extract data for submission to the National Alzheimer's Disease Coordinating Center. Core computer specialists also maintain the computer hardware and the systems level software needed for access to the analysis computers and to the databases via the internet, while at the same time keeping the computer systems up-to-date in terms of security, to prevent unauthorized access. Core computer specialists and research consultants are also available to provide some programming services, as needed, to all cores and projects. Core statistical geneticists and biostatisticians are available to all cores and projects for consultation and assistance regarding design, analysis, and interpretation of data, and preparation of manuscripts using such approaches. This includes evaluation, extension, and development of new analytical methodology and the authoring and coauthoring of manuscripts based on such new methods.

该核心的主要目的是为华盛顿大学阿尔茨海默氏病研究中心（ADRC）的核心和项目提供数据管理，统计遗传和生物统计学支持。我们的具体目的是：（1）为项目，核心和试点项目提供数据库管理支持；（2）在UW ADRC和其他ADC的统计和统计遗传设计和分析领域的项目，核心和试点项目提供支持； （3）协助与统计和统计遗传分析有关的手稿准备项目，核心和试点项目； （4）保持积极的提供这种支持的方法； （5）评估，开发，扩展和应用适当的统计 以及针对项目，核心和试点项目引起的问题的统计遗传学方法。核心计算机专家构建，修改和维护存储和访问ADRC数据以满足核心和项目的分析需求所需的数据库，并能够提取数据以提交给国家阿尔茨海默氏病协调中心。核心计算机专家还维护计算机硬件和系统级软件，可以通过Internet访问分析计算机和数据库，同时使计算机系统在安全性方面保持最新状态，以防止未经授权的访问。核心计算机专家和研究顾问也是 可根据需要为所有核心和项目提供一些编程服务。所有核心和项目都可以使用核心统计遗传学家和生物统计学家，以咨询和协助数据，分析和解释数据，并使用这种方法准备手稿。这包括新分析方法的评估，扩展和开发以及基于此类新方法的手稿的创作和合法化。