Understanding and Predicting Thermodynamic and Kinetic Stability in Pharmaceutical Hydrates

了解和预测药物水合物的热力学和动力学稳定性

• 批准号: 2784601
• 金额: --
• 依托单位: Durham University
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2784601
• 关键词: Understanding; Predicting; Thermodynamic; Kinetic; Stability

This project seeks to find links between the crystal structures of hydrates and their thermodynamic and kinetic stabilities. We are interested in developing new knowledge about what makes a hydrate structure stable or unstable and, therefore, unlikely or likely to change under several processing operations used in pharmaceutical manufacturing. The project will use a combination of experimental and computational approaches to estimate hydrate stability from crystal structure knowledge and predict solid form changes in hydrates upon various types of processing conditions (i.e. milling, storage...).

该项目旨在寻找水合物晶体结构与其热力学和动力学稳定性之间的联系。我们有兴趣开发关于水合物结构稳定或不稳定的新知识，因此在药品制造中使用的几种加工操作下不太可能或可能发生变化。该项目将结合实验和计算方法，根据晶体结构知识估计水合物稳定性，并预测水合物在各种加工条件（即研磨、储存……）下的固体形态变化。