The role of SUMO in regulating fungal diseases in crops plants through the chitin receptor CERK1.

SUMO 通过几丁质受体 CERK1 调节农作物真菌病害的作用。

• 批准号: 2784609
• 金额: --
• 依托单位: Durham University
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2784609
• 关键词: role; SUMO; regulating; fungal; diseases

Fungal disease management will become increasingly important for global food security in the coming years, especially in the face of climate change and increasing food demand. The development of disease resistant crops to fungal infection is central to this solution, so knowledge of the plant's immune response to fungal infection is essential for the development of crops with enhanced resistance. This thesis studies CERK1, the main pattern recognition receptor protein for chitin in plants, and it's interaction with SUMO during chitin elicitation. Additionally, the SUMO protease DeSi3a and its role during botrytis cinerea infection is explored. The working hypotheses for this study are that like FLS2, CERK1 is SUMOylated upon chitin elicitation and that this post-translational modification is essential for the activation of fungal immune signaling in the cell.

未来几年，真菌病管理对于全球粮食安全将变得越来越重要，特别是在气候变化和粮食需求不断增加的情况下。开发对真菌感染具有抗病性的作物是该解决方案的核心，因此了解植物对真菌感染的免疫反应对于开发具有增强抗性的作物至关重要。本论文研究了植物中几丁质的主要模式识别受体蛋白CERK1，及其在几丁质诱导过程中与SUMO的相互作用。此外，还探讨了 SUMO 蛋白酶 DeSi3a 及其在灰霉病感染过程中的作用。这项研究的工作假设是，像 FLS2 一样，CERK1 在几丁质诱导下被 SUMO 化，并且这种翻译后修饰对于细胞中真菌免疫信号的激活至关重要。