CLAUDE D.PEPPER OLDER AMERICANS INDEPENDENCE CENTERS

克劳德·D·佩珀美国老年人独立中心

• 批准号: 7125395
• 负责人: JEFFREY B. HALTER
• 金额: $ 15.3万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7125395
• 关键词: aging; clinical research; functional ability; geriatrics

DESCRIPTION (provided by applicant): This is a competing renewal application for support of the Claude D. Pepper Older Americans Independence Center (OAIC) at the University of Michigan (UM Pepper Center). The specific aims of the UM Pepper Center are: 1) To support research which has a focus on enhancing the independence of older adults by improved understanding of predictors and modulators of the aging phenotype, and its resulting health outcomes. 2) To help maintain and restore the independence of older people by supporting translational research linking basic and clinical research on aging and common health problems of older adults leading to disability. 3) To provide Research Resources Cores (RRCs) that support and assist investigator initiated research projects which can lead to new insights into the basic mechanisms underlying conditions that contribute to the aging phenotype and loss of independence of older adults, and Core Development Projects which develop and test innovative methods to apply to such research projects. 4) Through its Research Career Development Core (RCDC), to strengthen the UM environment for training of future academic leaders in geriatrics and aging who can conduct research on basic mechanisms contributing to the aging phenotype, can develop new methods to enhance translational research, and can carry out clinical trials of promising interventions to enhance independence of older adults. 5) Through its Pilot and Exploratory Studies Core (PESC), to attract UM junior faculty and senior faculty not previously involved in aging research to study problems predisposing to the aging phenotype and to carry out translational research to maintain and enhance independence of older adults. The UM Pepper Center has in place a well established leadership and administrative structure, the key elements of the RCDC and the PESC, and four RRCs, all of which were organized and funded under the auspices of the UM Pepper Center during the previous 14 years. These RRC's include the Human Subjects and Assessment Core (HSAC); the Biomechanies Core; the Methodology, Data Management and Analysis Core (MDMAC); and the Core Facility for Aged Rodents (CFAR). A new Genomic Analysis Core (GAC) is proposed in this application. Six Core Development Projects will strengthen the activities of theses RRCs. The RCDC features three central elements: 1) a competitive program to select promising UM junior faculty for salary support to conduct research relevant to the UM Pepper Center's research focus; 2) a research training program for junior faculty engaged in such research, and 3) a Mentorship Program that permits junior faculty members to work closely with one or more UM senior investigators.

描述（由申请人提供）：这是一份竞争性更新申请，旨在支持密歇根大学（UM Pepper 中心）的 Claude D. Pepper 美国老年人独立中心 (OAIC)。 UM Pepper 中心的具体目标是： 1) 支持重点关注通过提高对衰老表型的预测因素和调节因素及其由此产生的健康结果来增强老年人独立性的研究。 2) 通过支持将衰老和导致残疾的老年人常见健康问题的基础研究和临床研究联系起来的转化研究，帮助维持和恢复老年人的独立性。 3) 提供研究资源核心（RRC），支持和协助研究者发起的研究项目，这些项目可以对导致老年人表型和独立性丧失的基本机制产生新的见解，以及开发核心开发项目并测试应用于此类研究项目的创新方法。 4）通过其研究职业发展核心（RCDC），加强UM环境，培养未来老年病学和老龄化领域的学术领导者，他们可以对导致衰老表型的基本机制进行研究，可以开发新方法来加强转化研究，以及可以开展有希望的干预措施的临床试验，以增强老年人的独立性。 5）通过其试点和探索性研究核心（PESC），吸引以前未参与衰老研究的UM初级教师和高级教师来研究导致衰老表型的问题，并进行转化研究以维持和增强老年人的独立性。 UM Pepper 中心建立了完善的领导和行政结构，这是 RCDC 和 PESC 的关键要素，以及四个 RRC，所有这些都是在过去 14 年里在 UM Pepper 中心的支持下组织和资助的。这些 RRC 包括人类受试者和评估核心 (HSAC)；生物力学核心；方法、数据管理和分析核心（MDMAC）；和老年啮齿动物核心设施（CFAR）。本申请提出了一种新的基因组分析核心（GAC）。六个核心发展项目将加强这些 RRC 的活动。 RCDC 具有三个核心要素：1）一个竞争性计划，旨在选择有前途的 UM 初级教员提供薪资支持，以开展与 UM Pepper 中心研究重点相关的研究； 2）针对从事此类研究的初级教师的研究培训计划，以及 3）指导计划，允许初级教师与一名或多名密歇根大学高级研究人员密切合作。