COBRE: UD: PROJ 4: CORRECTION OF VARUS DEFORMITY BY AN OPENING WEDGE OSTEOTOMY

COBRE：UD：项目 4：通过开放楔形截骨术矫正内翻畸形

• 批准号: 7170579
• 负责人: KATHERINE S RUDOLPH
• 金额: $ 14.64万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-02-01 至 2006-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7170579
• 关键词: arthritis therapy; clinical research; disease /disorder prevention /control; knee; osteoarthritis

We propose to establish a center of biomedical research excellence at the University of Delaware that will focus on the prevention and treatment of osteoarthritis. This proposal involves three research projects, each lead by a junior faculty member who will be mentored by senior faculty. In Project 1, Dr. Manal proposes to use a biomedical model based on MRI and electromyographic data to examine knee kinematics and kinetics while performing activities of daily living. Project 2: In-shoe wedges have been shown to be an effective conservative approach in reducing pain in patients with osteoarthritis. The mechanism responsible for this pain reduction is not well understood. In our third project, Dr. Royer proposes to examine the examine the effects of in-shoe wedges in patients with knee OA on static alignment measures. In addition, the long-term effect of this treatment will also be examined. In Project 3, Dr. Rudolph proposes to study genu varum ("bowleggedness"), which often leads to arthritis on the medial compartment of the knee. Surgery is often performed to correct the alignment of the knee in people with genu varum by removing a wedge of bone on the lateral side of the tibia just below the knee joint to align the joint surfaces more normally (closing wedge osteotomy). Removing bone can increase the laxity of the joint capsule, muscles, and ligaments around the knee and may lead to increased problems with biomechanics and muscular responses. An alternative surgery, the opening wedge osteotomy involves the creation of an opening on the medial side of the tibia which can be distracted slowly over time. The purpose of this study is to characterize the differences in movement and muscle activity before and after an opening wedge osteotomy with callus distraction to correct genu varum.

我们建议在特拉华大学建立一个生物医学卓越研究中心，重点关注骨关节炎的预防和治疗。该提案涉及三个研究项目，每个项目均由一名初级教员领导，并由高级教员指导。在项目 1 中，Manal 博士建议使用基于 MRI 和肌电图数据的生物医学模型来检查进行日常生活活动时的膝盖运动学和动力学。项目 2：鞋内坡跟鞋已被证明是减轻骨关节炎患者疼痛的有效保守方法。这种减轻疼痛的机制尚不清楚。在我们的第三个项目中，Royer 博士建议检查鞋内楔子对膝关节 OA 患者静态对准测量的影响。此外，还将检查这种治疗的长期效果。在项目 3 中，鲁道夫博士建议研究膝内翻（“罗圈腿”），这种疾病通常会导致膝关节内侧间室关节炎。通常进行手术来矫正膝内翻患者的膝关节排列，方法是去除膝关节下方胫骨外侧的楔形骨，以使关节表面更正常地排列（闭合楔形截骨术）。去除骨头会增加膝盖周围关节囊、肌肉和韧带的松弛，并可能导致生物力学和肌肉反应问题增加。另一种手术是开放式楔形截骨术，涉及在胫骨内侧创建一个开口，随着时间的推移，该开口可以慢慢地分散。本研究的目的是描述通过骨痂牵引矫正膝内翻的开放楔形截骨术前后运动和肌肉活动的差异。