COBRE: UD: PROJ 4: CORRECTION OF VARUS DEFORMITY BY AN OPENING WEDGE OSTEOTOMY

COBRE：UD：项目 4：通过开放楔形截骨术矫正内翻畸形

• 批准号: 7609992
• 负责人: KATHERINE S RUDOLPH
• 金额: $ 27.56万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7609992
• 关键词: Accounting; American; Anatomy; Bone callus; Compatible; Computer Retrieval of Information on Scientific Projects Database; Deformity; Degenerative polyarthritis; Funding; Goals; Grant; Individual; Institution; Joint Instability; Joints; Knee; Knee Osteoarthritis; Knee joint; Ligaments; Medial; Modeling; Motion; Movement; Muscle; Muscle Weakness; Operative Surgical Procedures; Osteotomy; Pain; Patients; Pattern; Persons; Procedures; Proprioception; Purpose; Research; Research Personnel; Resources; Sensory; Side; Skeletal system; Source; Structure; Time; United States National Institutes of Health; Walking; articular cartilage; bone; distraction; functional disability; functional outcomes; muscle strength; response; tibia

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Osteoarthritis (OA), a progressive destruction of articular cartilage, ultimately leads to joint space narrowing, progressive erosion of bone and ligament laxity. Knee OA is often associated with disabling pain and accounts for a large portion of functional disability in older Americans. The medial compartment of the knee is most frequently involved and is associated with medial joint space narrowing, genu varum and laxity of the medial joint structures. Genu varum itself leads to an excessive adduction moment at the knee that may exacerbate the progression of the OA. Progression of knee OA also involved an intricate interaction between muscle weakness, sensory loss and knee instability, all of which are negatively effected by the bony malalignment. Realignment procedures performed to correct the varus deformity in active individuals provide a model for assessment of the effect of skeletal alignment on thosevariables purported to contribute to the progression of knww OA, muscle weakness, proprioception, knee joint laxity, and function. The overall goal of this study is to determine whether anatomic realignment of the tibiofemoral joint in patients with moderate genu varus deformity allows for changes in muscle strength, knee joint laxity, knee joint instability and proprioception that is compatible with halting the progression of knee OA. Aim 1: demonstrate the effect of anatomic realignment of the tibiofemoral joint in restoring quadriceps activation, quadriceps strength and mediolateral joint stability in persons with painful, medial compartment OA. Aim 2: demonstrate the effect of anatomic realignment of the tibiofemoral joint on normalization of muscle activation and movement patterns (timing, level of activation and degree of co-contraction) during walking in persons with painful, medial compartment OA. Aim 3: demonstrate the effect of anatomic realignment of the tibiofemoral joint on normalization of the neuromuscular response to a medial perturbation at the knee in persons with painful, medial compartment OA. Aim 4: Predict functional outcome from linear combinations of quadriceps function, knee motion, moments, and neuromuscular responses in people with painful, medial compartment OA and genu varum before and after anatomic realignment of the tibiofemoral joint. An alternative surgery, the opening wedge osteotomy involves the creation of an opening on the medial side of the tibia which can be distracted slowly over time. The purpose of this study is to characterize the differences in movement and muscle activity before and after an opening wedge osteotomy with callus distraction to correct genu varum.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 骨关节炎（OA）是关节软骨的进行性破坏，最终导致关节空间变窄，骨骼和韧带松弛的逐渐侵蚀。 膝盖OA通常与残疾的疼痛有关，并说明了老年人的大部分功能残疾。 膝盖的内侧隔室最常参与，并且与内侧关节结构的内侧关节空间变窄，真实的和松弛有关。 纯横梁本身会导致膝盖上过度的上内力矩，这可能会加剧OA的进展。 膝盖OA的进展还涉及肌肉无力，感觉丧失和膝关节不稳定性之间的复杂相互作用，所有这些相互作用都受到骨质疾病的负面影响。 为了纠正活性个体的变化畸形而执行的重新检查程序为评估骨骼比对的影响对骨骼比对的影响，对那些声称有助于KNWW OA的进展，肌肉无力，前骨，膝关节关节松弛和功能的影响。 这项研究的总体目的是确定中等肌肉畸形患者的胫骨关节的解剖学重新调整是否可以改变肌肉强度，膝关节松弛，膝关节关节不稳定性和前置感受，这与抗膝关节的进展兼容。 AIM 1：证明胫骨关节对股四头肌激活，股四头肌强度和中外侧关节稳定性在具有疼痛，内侧隔室OA的患者中的效果。 AIM 2：证明胫骨关节解剖学重新对齐对肌肉激活和运动模式的归一化（时机，激活水平和共同收集程度）的归一化，在疼痛，内侧隔室OA的人中行走时。 AIM 3：证明胫骨关节解剖学重新对齐对神经肌肉反应对内侧扰动的神经肌肉反应的标准化对疼痛，内侧隔室OA的人的影响。 AIM 4：通过痛苦的，内侧室OA和tee rum的人的股四头肌功能，膝盖运动，力矩和神经肌肉反应的线性组合预测功能结果，在胫骨女性关节的解剖学重新调整之前和之后。 开口楔截骨术是另一种手术，涉及在胫骨内侧的开口创建，随着时间的流逝，可以缓慢分散注意力。这项研究的目的是表征开放楔形截骨术之前和之后的运动和肌肉活动的差异，并分散了愈伤组织，以纠正真正的杂色。