KNEE STIFFNESS, PROPRIOCEPTION AND INSTABILITY AFFECT KNEE CONTROL IN OA

膝关节僵硬、本体感觉和不稳定会影响 OA 患者的膝关节控制

• 批准号: 8359774
• 负责人: KATHERINE S RUDOLPH
• 金额: $ 28.6万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8359774
• 关键词: Affect; Cartilage; Centers of Research Excellence; Characteristics; Degenerative polyarthritis; Disease Progression; Engineering; Funding; Goals; Grant; Joint Laxity; Knee; Knowledge; Medial; Mentors; Muscle; National Center for Research Resources; Patients; Principal Investigator; Proprioception; Rehabilitation therapy; Research; Research Infrastructure; Resources; Science; Screening procedure; Source; United States National Institutes of Health; Woman; Work; career; cost; improved; improved functioning; joint function; joint injury; programs; quadriceps muscle; rehabilitation strategy; tool; Affect; Cartilage; Centers of Research Excellence; Characteristics; Degenerative polyarthritis; Disease Progression; Engineering; Funding; Goals; Grant; Joint Laxity; Knee; Knowledge; Medial; Mentors; Muscle; National Center for Research Resources; Patients; Principal Investigator; Proprioception; Rehabilitation therapy; Research; Research Infrastructure; Resources; Science; Screening procedure; Source; United States National Institutes of Health; Woman; Work; career; cost; improved; improved functioning; joint function; joint injury; programs; quadriceps muscle; rehabilitation strategy; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. A myriad of studies have identified that people with medial knee OA (MKOA) typically have weak quadriceps femoris muscles, excessive knee adduction moments and excessive mediolateral joint laxity all of which can contribute to erosion of cartilage in the knee. However, other than quadriceps strengthening programs, there is a dearth of rehabilitation strategies that have shown marked improvement of joint function. The long term goal of this work is to develop patient specific rehabilitation programs to help improve function while reducing the progression of MKOA. The goal of the proposed work is to understand how quadriceps strength, knee stiffness, proprioception and instability contribute to disease progression and if medial muscle co-contraction is a strategy that will reduce or exacerbate the progression of OA. The knowledge gained in the study will allow us to understand which modifiable characteristics (knee stiffness and instability, and medial muscle co-contraction) will improve knee function without further joint damage and to develop screening tools that properly identify patients who will benefit from the rehabilitation programs. Dr. Buchanan will serve as scientific mentor and Dr. Snyder-Mackler will be career mentor.

该副本是利用资源的众多研究子项目之一 由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持 而且，副投影的主要研究员可能是其他来源提供的 包括其他NIH来源。 列出的总费用可能 代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。 无数的研究已经确定，内侧膝盖OA（MKOA）的人通常股股四头肌肌肉肌肉较弱，膝关节内收肌过量和过度的中外侧关节松弛性，所有这些都会导致膝盖软骨的侵蚀。 但是，除了加强股四头肌增强计划之外，还缺乏康复策略，这些策略已显示出明显的关节功能。这项工作的长期目标是制定特定于患者的康复计划，以帮助提高功能，同时减少MKOA的发展。 拟议工作的目的是了解股四头肌的强度，膝盖僵硬，本体感受和不稳定性如何有助于疾病的进展，以及内侧肌肉共获得的策略是否会减少或加剧OA的进展。 研究中获得的知识将使我们能够了解哪些可修改特征（膝盖僵硬和不稳定性以及内侧肌肉共同收缩）将改善膝关节功能，而无需进一步的关节损害，并开发了筛查工具，这些工具可以正确识别将从康复计划中受益的患者。 Buchanan博士将担任科学导师，Snyder-Mackler博士将担任职业导师。