Collaborative Pediatric Critical Care Research Network

儿科重症监护协作研究网络

• 批准号: 6930181
• 负责人: KATHLEEN L. MEERT
• 金额: $ 12.5万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-05-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6930181
• 关键词: behavioral /social science research tag; bereavement; clinical research; communication; cooperative study; critical care; death; emotional adjustment; family structure /dynamics; human subject; human therapy evaluation; intensive care; interview; longitudinal human study; marriage /marital status; meeting /conference /symposium; mental health epidemiology; parent deprivation; patient care personnel relations; pediatrics; psychological stressor; questionnaires; social support network; videotape /videodisc

DESCRIPTION (provided by applicant): The overall aim of this proposal is for Wayne State University (WSU) to be a part of the NICHD Collaborative Pediatric Critical Care Research Network. The Network will bring together a core of pediatric intensivists with the research expertise and clinical skill to investigate the safety, efficacy, and risk/benefit/cost ratios of novel treatments and management strategies for critically ill and injured children. The Network will conduct a wide range of transdisciplinary research including epidemiologic studies of life-threatening diseases, descriptive and translational studies of the pathophysiology of inflammation and organ failure, randomized trials of drugs, procedures and other interventions specifically evaluating their effect on long-term outcomes, and behavioral studies of the effect of critical illness on the child and his/her family. The Pediatric Critical Care Medicine (PCCM) faculty at WSU is responsible for the state-of-the-art, multidisciplinary 20-bed PICU that has 1,400 medical and surgical admissions annually. The PCCM faculty has conducted many randomized trials and observational studies in the PICU, and participated in other multicenter research networks. The faculty has a long history of collaboration with pediatric surgeons. Strengths of WSU include membership in the NICHD Pediatric Pharmacology Research Network, the Neonatal Research Network, the Maternal Fetal Network, the Children's Oncology Group, and its capability for long-term follow-up of patients in clinical trials. The concept proposal will test the hypothesis that a physician-parent postmortem conference 3 months after a child's death in the PICU can reduce the likelihood of pathological grief and subsequent family break-up. Aim 1 will develop the postmortem conference as a strategic communication encounter. Aim 2 will evaluate the longitudinal effect of the postmortem conference on pathological grief, psychological distress and marital dysfunction in bereaved parents. Aim 3 will evaluate risk factors for pathological grief, psychological distress and marital dysfunction, and the effect of the postmortem conference in the identified high-risk groups.

描述（由申请人提供）：该提案的总体目标是让韦恩州立大学 (WSU) 成为 NICHD 儿科重症监护协作研究网络的一部分。该网络将汇集具有研究专业知识和临床技能的儿科重症专家核心人员，以研究针对危重病和受伤儿童的新型治疗和管理策略的安全性、有效性以及风险/效益/成本比。该网络将开展广泛的跨学科研究，包括危及生命的疾病的流行病学研究、炎症和器官衰竭病理生理学的描述性和转化性研究、药物、手术和其他干预措施的随机试验，专门评估其对长期结果的影响，以及危重疾病对儿童及其家人影响的行为研究。 WSU 儿科重症监护医学 (PCCM) 教员负责拥有最先进的多学科 20 个床位的 PICU，每年收治 1,400 名内科和外科患者。 PCCM 教师在 PICU 进行了许多随机试验和观察性研究，并参与了其他多中心研究网络。该学院与儿科外科医生有着悠久的合作历史。 WSU 的优势包括 NICHD 儿科药理学研究网络、新生儿研究网络、母胎网络、儿童肿瘤学组的成员资格，以及对临床试验中患者进行长期随访的能力。该概念提案将检验以下假设：儿童在儿科重症监护病房 (PICU) 死亡后 3 个月举行医生与家长尸检会议可以减少病理性悲伤和随后家庭破裂的可能性。目标 1 将事后分析会议发展为一次战略沟通会。目标 2 将评估尸检会议对失去亲人的父母的病理性悲伤、心理困扰和婚姻功能障碍的纵向影响。目标 3 将评估病理性悲伤、心理困扰和婚姻功能障碍的危险因素，以及尸检会议对已确定的高危人群的影响。