STEM CELL GENE THERAPY FOR AIDS USING AN ANTI-HIV ENVELOPE ANTISENSE MOLECULE

使用抗 HIV 包膜反义分子治疗艾滋病的干细胞基因疗法

• 批准号: 7165549
• 负责人: Stephen E. Braun
• 金额: $ 16.81万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-05-01 至 2006-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7165549
• 关键词: Primates; animal colony

DESCRIPTION (provided by applicant): This renewal application requests five years of funding for the continuation of the NENPRC's multidisciplinary biomedical research and resource program. The investigators will continue to pursue the National Institutes of Health (NIH) directed mission of utilizing the unique characteristics of nonhuman primates (NHPs) to conduct meritorious research that contributes to the understanding and solution of human health diseases. To further this objective, the emphasis of the application is to provide support for seven science cores (Behavioral Biology, Comparative Pathology, Immunology, Microbiology, Neurochemistry, Primate Resources, and Tumor Virology); to conduct pilot research; and provide Center-wide support services with emphasis on the pathogenesis of infectious diseases, treatment and prophylaxis of AIDS, basic immunology, ongenicity of herpesvirus, neurodegenerative diseases, and drug addiction. Additionally, this proposal seeks to: 1) enhance the Center's ability to serve as a regional, national, and international resource for collaborative, affiliate, and visiting scientists by providing specialized facilities, equipment, and technological expertise; 2) enhance the availability of NHPs for use in biomedical research; 3) train young investigators; and 4) provide the administrative, scientific, and primate resources infrastructure necessary to maintain and operate a Center. Four colony health-related resource projects are also included in this application as well as a five year Improvement and Modernization Program. The NENPRC, HMS, is fully accredited by the American Association for the Accreditation of Laboratory Animal Care (AAALAC) International.

描述（由申请人提供）： 该更新申请要求五年的资金来继续NENPRC的多学科生物医学研究和资源计划。 调查人员将继续追求美国国立卫生研究院（NIH）的执行任务，以利用非人类灵长类动物（NHP）的独特特征来进行有助于理解和解决人类健康疾病的功绩研究。 为了进一步，该应用的重点是为七个科学核心提供支持（行为生物学，比较病理学，免疫学，微生物学，神经化学，灵长类动物资源和肿瘤病毒学）；进行试点研究；并提供中心的支持服务，重点是传染病的发病机理，艾滋病治疗和预防，基本免疫学，疱疹病毒的基因，神经退行性疾病和吸毒成瘾。 此外，该提案试图：1）通过提供专业的设施，设备和技术专长，增强了中心作为协作，分支机构和访问科学家的区域，国家和国际资源的能力； 2）增强用于生物医学研究的NHP的可用性； 3）培训年轻调查员； 4）提供维护和运营中心所需的行政，科学和灵长类动物资源基础设施。 该应用程序还包括四个与Colony Health相关的资源项目，以及五年的改进和现代化计划。 NENPRC HMS已获得美国实验室动物护理认证协会（AAAALAC）国际的完全认可。