Mechanisms controlling liver development in zebrafish

控制斑马鱼肝脏发育的机制

• 批准号: 7273476
• 负责人: CHONG H SHIN
• 金额: $ 5.2万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-08 至 2008-08-07
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7273476
• 关键词: Adult; Affect; Amino Acids; Animal Model; Antibodies; Bile fluid; Biological Assay; Biological Models; Cell Death; Cell Proliferation; Classification; Clinical; Defect; Development; Embryo; Embryonic Development; Endoderm; Event; Fellowship; Genes; Genetic; Genetic Screening; Goals; Growth; Hepatocyte; Hepatocyte Growth Factor; In Vitro; Individual; Knockout Mice; Laboratories; Learning; Lesion; Liver; Maps; Mesenchyme; Messenger RNA; Molecular; Names; Natural regeneration; Organ; Pathway interactions; Pattern; Physiological; Process; Production; Proliferating; Research Proposals; Research Training; Role; Signal Pathway; Staging; Therapeutic; Tissues; Tube; Vertebrates; Zebrafish; base; blood filtration; gain of function; gastrointestinal system; gene function; in vivo; insight; migration; mutant; positional cloning; prevent; receptor; sugar; tool

DESCRIPTION (provided by applicant): Understanding the mechanisms involved in liver development is essential for answering how the liver acquires its physiological function. In addition, understanding the molecular events controlling the development of the embryonic as well as adult liver has the promise of providing a variety of therapeutic tools useful in clinical settings aimed at regulating liver growth and regeneration. This proposal aims at understanding the mechanisms controlling liver development using zebrafish as a model system.

描述（由申请人提供）： 了解肝发育中涉及的机制对于回答肝脏如何获得其生理功能至关重要。此外，了解控制胚胎发展和成年肝脏发展的分子事件也有望提供各种用于调节肝脏生长和再生的临床环境中有用的治疗工具。该建议旨在了解使用斑马鱼作为模型系统控制肝脏发育的机制。