Mechanisms controlling liver development in zebrafish

控制斑马鱼肝脏发育的机制

• 批准号: 7122331
• 负责人: CHONG H SHIN
• 金额: $ 5.04万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-08 至 2008-08-07
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7122331
• 关键词: antisense nucleic acid; biological models; cell growth regulation; cell migration; cell proliferation; developmental genetics; genetic screening; histogenesis; liver; molecular pathology; molecular probes; mutant; nonmammalian vertebrate embryology; postdoctoral investigator; zebrafish

DESCRIPTION (provided by applicant): Understanding the mechanisms involved in liver development is essential for answering how the liver acquires its physiological function. In addition, understanding the molecular events controlling the development of the embryonic as well as adult liver has the promise of providing a variety of therapeutic tools useful in clinical settings aimed at regulating liver growth and regeneration. This proposal aims at understanding the mechanisms controlling liver development using zebrafish as a model system.

描述（由申请人提供）： 了解肝脏发育的机制对于回答肝脏如何获得其生理功能至关重要。此外，了解控制胚胎和成人肝脏发育的分子事件有望提供多种可用于临床环境的治疗工具，旨在调节肝脏生长和再生。该提案旨在了解使用斑马鱼作为模型系统控制肝脏发育的机制。