Disrupting and Delivering: A New Approach to Tackling Biofilm Infections

颠覆与交付：应对生物膜感染的新方法

• 批准号: 2819847
• 金额: --
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2819847
• 关键词: Disrupting; Delivering; New; Approach; Tackling

In this project we aim to use physical stimuli and targeted liposomal delivery to disrupt and sensitise biofilms for the delivery of antimicrobial drugs. The primary focus will be on antibiotic-resistant lung infections, using targeted delivery to Gram-negative bacteria. We will develop a microfluidic-based high throughput screening platform combining acoustic manipulation and optical tweezers to evaluate the therapeutics, and use a range of biophysical techniques to characterise them during formulation development

在这个项目中，我们旨在使用物理刺激和靶向脂质体递送来破坏和敏感生物膜以递送抗菌药物。主要的重点将用于使用针对革兰氏阴性细菌的靶向递送抗生素肺部感染。我们将开发一个基于微流体的高吞吐量筛选平台，结合声学操纵和光学镊子来评估治疗疗法，并使用一系列生物物理技术在配方开发过程中表征它们