Coatings for Biostable Neural Prostheses

用于生物稳定神经假体的涂层

• 批准号: 7235792
• 负责人: HILTON G PRYCE LEWIS
• 金额: $ 8.51万
• 依托单位: GVD CORPORATION
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7235792
• 关键词: bioengineering /biomedical engineering; biomaterial compatibility; biomaterial development /preparation; electrodes; implant; laboratory rabbit; medical implant science; nervous system prosthesis; surface coating; surgery material /equipment

DESCRIPTION (provided by applicant): The miniaturization of neuroprosthetic technology has led to an urgent need for thin (10 mu m or less) insulating coatings that retain their biocompatibility and stability over long periods. Initiated Chemical Vapor Deposition (iCVD) is an alternative to applying polymers using solvent-based techniques or a powder spraying methods. Under the Phase I funding, an iterative process was used to identify a window of iCVD processing conditions that successfully provided electrical insulation to 25 mu m diameter gold lead wires. The coating was tested after physical stressing and exposure to a simulated biological environment and the integrity, adhesion, and insulating abilities of GVD's PTFE coating were proven in short-term testing. A key study in the Phase I project was the comparison between GVD's PTFE coated wires and other leading commercial coatings including Parylene-C, silicone, and commercially available Teflon(r) coatings. Our study showed that GVD's PTFE coating out-performed all other coatings by providing enhanced electrical insulation while reducing the overall wire diameter. The goal of the Phase II project is to expand the use of thin iCVD PTFE coatings for insulating and protecting neural probe assemblies. This will be accomplished by designing equipment capable of coating sufficient numbers of prototypes for testing, optimizing the process for coating 3D substrates, further research into adhesion promotion strategies for the substrates of interest and long term testing of the coating's biocompatibility. The new equipment will allow us to coat wires of different materials and several types of neural prosthetic prototypes for evaluation and long-term testing. The ultimate goal is to achieve single step encapsulation of three-dimensional neural probe arrays and of neural prosthetic assemblies. At the end of this Phase II work, GVD will be able to offer to researchers and manufacturers a proven, effective solution to the problems of insulation and encapsulation of neuroprosthetic devices. This will enable greater flexibility in the design of these devices, the choice of materials used, and the minimum dimensions which can be achieved. The therapeutic benefit will be to de-bottleneck the development of these devices and accelerate their proliferation as treatments for neurological disorders.

描述（由申请人提供）：神经假体技术的小型化导致迫切需要薄（10μm或更小）的绝缘涂层，以长期保持其生物相容性和稳定性。引发化学气相沉积 (iCVD) 是使用溶剂型技术或粉末喷涂方法涂覆聚合物的替代方法。在第一阶段的资助下，使用迭代过程来确定 iCVD 处理条件的窗口，成功地为 25 μm 直径的金引线提供电绝缘。该涂层在物理应力和暴露于模拟生物环境后进行了测试，GVD PTFE 涂层的完整性、附着力和绝缘能力在短期测试中得到了证明。第一阶段项目的一项关键研究是对 GVD 的 PTFE 涂层线材与其他领先的商业涂层（包括聚对二甲苯-C、有机硅和市售 Teflon(r) 涂层）进行比较。我们的研究表明，GVD 的 PTFE 涂层在提供增强的电绝缘性的同时减小了线材的总直径，从而优于所有其他涂层。第二阶段项目的目标是扩大 iCVD PTFE 薄涂层的使用，以绝缘和保护神经探针组件。这将通过设计能够涂覆足够数量的原型进行测试的设备、优化涂覆 3D 基材的工艺、进一步研究感兴趣基材的粘附促进策略以及涂层生物相容性的长期测试来实现。新设备将使我们能够涂覆不同材料的线材和多种类型的神经假体原型，以进行评估和长期测试。最终目标是实现三维神经探针阵列和神经假体组件的一步封装。在第二阶段工作结束时，GVD 将能够为研究人员和制造商提供经过验证的有效解决方案，解决神经假体装置的绝缘和封装问题。这将为这些设备的设计、所用材料的选择以及可实现的最小尺寸提供更大的灵活性。治疗益处将是消除这些设备的开发瓶颈，并加速它们作为神经系统疾病治疗方法的扩散。