Coatings for Biostable Chronic Neural Prostheses

用于生物稳定慢性神经假体的涂层

• 批准号: 6832980
• 负责人: HILTON G PRYCE LEWIS
• 金额: $ 10万
• 依托单位: GVD CORPORATION
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-15 至 2004-12-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6832980
• 关键词: bioengineering /biomedical engineering; biomaterial compatibility; biomaterial development /preparation; electrodes; implant; medical implant science; nervous system prosthesis; surface coating; surgery material /equipment

DESCRIPTION (provided by applicant): This Small Business Innovation Research Phase I grant will support the development and testing of a PTFEcoating prepared using GVD's patented hot filament chemical vapor deposition (HFCVD) process as an insulator for neural prostheses. The project will focus specifically on insulating coatings for the lead wires used in neuroprosthetic assemblies. In addition to electrical resistivity, these coatings will be biocompatible, stable in biological environment, ultra-thin, have good adhesion, flexibility, durability and Iow-k dielectric. Current coatings -- i.e., parylene, silicone, conventional PTFE -- are inadequate for the needs of future neuroprosthetic devices, in particular with respect to material stability, integrity and thinness. Beginning with cochlear implants nearly 30 years ago and, more recently, the introduction of brain pacemakers and cortical visual implants, neural prostheses are positioned to become an increasingly common treatment of a number! of neuro ogica d sorders. Coatings and surface treatments are an integral part of the device and key to performance. The specific aims of this project are to develop several grades of PTFE coating, create samples on various wires used in neuroprosthetic devices and test for mechanical, electrical properties, and biocompatibility and stability under biological environments. Long term the objective is threefold: (1) to commercialize these coatings for neural prostheses via licensing and equipment sales to device manufacturers or coating services, (2) to expand these coatings to other medical devices, and (3) to create additional coatings using GVD's proprietary HFCVD process.

描述（由申请人提供）：这个小型企业创新研究阶段I赠款将支持使用GVD专利的热丝化学蒸气沉积（HFCVD）作为神经假体绝缘体制备的PTFECOETing的开发和测试。该项目将专门针对神经假体组件中使用的铅线的绝缘涂层。除了电阻率外，这些涂层还具有生物相容性，在生物环境中稳定，超薄，具有良好的粘附，柔韧性，耐用性和IOW-K介电介电。 当前的涂层 - 即parylene，硅树脂，常规PTFE-不足以满足未来神经假体设备的需求，特别是在材料稳定性，完整性和薄度方面。从大约30年前的耳蜗植入物开始，最近引入了脑性起搏器和皮质视觉植入物，神经假体被定位为对许多人的日益普遍治疗！神经ogica d sorders。涂料和表面处理是设备不可或缺的一部分，是性能的关键。该项目的具体目的是开发多种PTFE涂层，在神经假体设备中使用的各种电线上创建样品，并测试生物环境下的机械，电性能以及生物相容性和稳定性。长期目标是三倍：（1）通过向设备制造商或涂料服务的许可和设备销售为神经假体商业化这些涂料，（2）将这些涂料扩展到其他医疗设备，以及（3）使用其他涂料来使用其他涂料。 GVD的专有HFCVD流程。