Coatings for Biostable Chronic Neural Prostheses

用于生物稳定慢性神经假体的涂层

• 批准号: 6741369
• 负责人: HILTON G PRYCE LEWIS
• 金额: $ 10.01万
• 依托单位: GVD CORPORATION
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-15 至 2004-10-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6741369
• 关键词: biomaterial compatibility; biomaterial development /preparation; biomedical equipment development; copolymer; electrical property; nervous system prosthesis; organosilicon compound; physical property; scanning electron microscopy; surface coating; tensile strength

DESCRIPTION (provided by applicant): This Small Business Innovation Research Phase I grant will support the development and testing of a fluorosilicone co-polymer coating prepared using GVD's patented nanotechnology coating process, as an insulating coating for neural prostheses. The project will focus on two specific parts of the neuroprosthetic device: lead wires and probes. In addition to electrical resistivity, these coatings will be biocompatible, stable in biological environment, ultra-thin, have good adhesion, flexibility, durability and Iow-k dielectric. Beginning with cochlear implants nearly 30 years ago and, more recently, the introduction of brain pacemakers and cortical visual implants, neural prostheses are positioned to become an increasingly common treatment of a number of neurological disorders, bringing hope to tens of millions of patients worldwide who suffer from neurological disorders such as Parkinson's disease, deep depression, and epilepsy, and don't respond to existing treatments. Coatings and surface treatments are an integral part of neuroprosthetic devices and key to their performance. Current coatings -- i.e., parylene, silicone, conventional PTFE -- are inadequate for the needs of future neuroprosthetic devices, in particular with respect to material stability, integrity and thinness. The specific aims of this project are to develop several grades fluorosilicone co-polymer coating, create samples on various wires used in neuroprosthetic devices and test for mechanical, electrical properties, and biocompatibility and stability under biological environments, and to compare with competing coating materials. Long term the objective is threefold: (1) to commercialize these coatings for neural prostheses via licensing and equipment sales to device manufacturers or coating services, (2) to expand these coatings to other medical devices, and (3) to create additional coatings using GVD's proprietary nanotechnology process.

描述（由申请人提供）：这项小企业创新研究第一阶段拨款将支持使用 GVD 的专利纳米技术涂层工艺制备的氟硅酮共聚物涂层的开发和测试，作为神经假体的绝缘涂层。该项目将重点关注神经假体装置的两个特定部分：引线和探针。除了电阻率之外，这些涂层还将具有生物相容性、在生物环境中稳定、超薄、具有良好的附着力、柔韧性、耐用性和低k介电性。 从近 30 年前的人工耳蜗开始，到最近大脑起搏器和皮质视觉植入物的推出，神经假体已成为治疗多种神经系统疾病的越来越常见的方法，为全球数千万患者带来希望。患有帕金森病、深度抑郁症和癫痫等神经系统疾病，并且对现有治疗没有反应。涂层和表面处理是神经假体装置不可或缺的一部分，也是其性能的关键。目前的涂层——即聚对二甲苯、硅胶、传统聚四氟乙烯——不足以满足未来神经假体装置的需求，特别是在材料稳定性、完整性和薄度方面。该项目的具体目标是开发多个等级的氟硅共聚物涂层，在神经假体装置中使用的各种电线上制作样品，并测试生物环境下的机械、电气性能以及生物相容性和稳定性，并与竞争涂层材料进行比较。 长期目标有三个：(1) 通过向设备制造商或涂层服务机构授予许可和设备销售，将这些用于神经假体的涂层商业化；(2) 将这些涂层扩展到其他医疗设备；(3) 使用GVD 专有的纳米技术工艺。