Intracranial Brain Function Mapping System

颅内脑功能图谱系统

• 批准号: 7053029
• 负责人: JAMES Samuel BRYAN
• 金额: $ 17.19万
• 依托单位: ASTRO-MED, INC.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-05-01 至 2006-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7053029
• 关键词: brain; clinical research; computers; electrodes; epilepsy; surgery

DESCRIPTION (provided by applicant): We will develop a modern, computer-controlled electrical stimulator for performing functional mapping by cortical stimulation. The primary application is for use with patients who are candidates for surgery to control or eliminate occurrence of epileptic seizures. Other applications will include functional mapping to plan surgery for other brain diseases such as tumors and research on brain electrical stimulation to control seizures. The need and specifications for the system come from recommendations of an expert panel of clinical users who have been consulted throughout the conception and Phase I research and will continue to be consulted in Phase II. In Phase I, we solved key technical issues associated with the design of the electrical stimulator and EEG amplifiers to minimize the interference to the exquisitely sensitive EEG amplifiers caused by the relatively huge electrical stimulation pulses. In Phase II, we will utilize the knowledge gained in Phase I to build two prototype systems. These will be tested on epilepsy patients in the normal course of their hospitalization for pre-surgical evaluation.

描述（由申请人提供）：我们将开发一种现代的，计算机控制的电刺激器，用于通过皮质刺激进行功能映射。主要的应用是用于候选手术的患者，以控制或消除癫痫发作的发生。其他应用将包括功能映射以计划其他脑部疾病的手术，例如肿瘤和研究脑电刺激以控制癫痫发作。该系统的需求和规格来自临床用户专家小组的建议，这些专家小组在整个概念和第一阶段研究中都得到了咨询，并将在第二阶段继续咨询。在第一阶段，我们解决了与电刺激器和脑电图放大器的设计相关的关键技术问题，以最大程度地减少对相对较大的电刺激脉冲引起的精确敏感的脑电图放大器的干扰。在第二阶段，我们将利用I阶段中获得的知识来构建两个原型系统。这些将在住院正常过程中对癫痫患者进行测试，以进行手术前评估。