Intracranial Brain Function Mapping System

颅内脑功能图谱系统

• 批准号: 6647391
• 负责人: JAMES Samuel BRYAN
• 金额: $ 10.71万
• 依托单位: ASTRO-MED, INC.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-05-01 至 2004-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6647391
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; brain mapping; computer assisted diagnosis; electrochemistry; electroencephalography; electrostimulus; image guided surgery /therapy; image processing

DESCRIPTION (provided by applicant): A computer controlled switching stimulator/amplifier is proposed which is capable of delivering electrical stimuli between pairs of intracranial electrodes, while simultaneously monitoring the EEG potentials on all implanted electrodes immediately before and after stimulus application In phase 1, a key feasibility issue will be to study the electro-chemical effects that that leave residual potentials on the electrodes immediately after stimulation which can block viewing the EEG. The knowledge gained will be used to build a breadboard EEG amplifier-stimulus generator combination which will permit recording and observation of the EEG in the stimulated channel as soon as possible after termination of the stimulus waveform train. Phase 2 will have the specific aim of embodying the design into a marketable product capable of expansion to at least 128 channels. Two 128 channel systems will be built. The developed hardware and software will be beta tested using human subjects who would normally be scheduled for clinical functional mapping prior to resective brain surgery for epilepsy. The technology developed will also be useful for brain functional mapping preceding other resective surgery such as for tumors.

描述（由申请人提供）：提出了一个计算机控制的开关刺激器/放大器，能够在颅内电极对之间传递电刺激，同时监视所有植入电极上的EEG潜在的EEG潜力，并在第1阶段的刺激上立即进行刺激的刺激效果，该刺激的电位可能会在刺激上进行，这是一个关键的可行性，这些刺激均可在启用电位上，该刺激效果会涉及电动效应，该刺激效果，该刺激效果，该刺激的效果，该刺激效果，该刺激效果效果，该刺激效果效果，该效果效果效果，该效果效果效果，查看脑电图。所获得的知识将用于构建面包板EEG放大器刺激器的组合，该组合将允许在刺激波形序列终止后尽快在刺激通道中记录和观察EEG。第2阶段的特定目的是将设计体现为可销售的产品，能够扩展至至少128个渠道。将构建两个128频道系统。开发的硬件和软件将使用人类受试者进行Beta测试，这些受试者通常会安排在重新脑手术癫痫之前进行临床功能映射。开发的技术也将用于在其他切除手术之前（例如肿瘤）之前的大脑功能映射。