Nuclear envelope membrane proteins and nuclear structure

核膜膜蛋白和核结构

• 批准号: 7112750
• 负责人: MEGAN C KING
• 金额: $ 4.6万
• 依托单位: ROCKEFELLER UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-15 至 2008-05-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7112750
• 关键词: cell component structure /function; membrane activity; membrane proteins; membrane structure; nuclear membrane; postdoctoral investigator; protein protein interaction; protein structure function

DESCRIPTION (provided by applicant): The nuclear envelope (NE) has long been appreciated as a gatekeeper to the genome of eukaryotic cells, restricting genomic access only to those molecules capable of traversing the NE via nuclear pore complexes (NPCs). It is increasingly evident, however, that the NE performs active and essential roles in genomic organization beyond providing simple compartmentalization of DMA. NE-associated complexes are important for maintenance of chromatin structure, gene regulation, and DMA replication. Disruption of the NE structure can lead to disregulation of these processes. This proposal focuses on the role of NE membrane proteins in maintaining the structural integrity provided by the NE, with a particular focus on the role of the transmembrane (TM) and lumenal domains of NE membrane proteins.

描述（由申请人提供）：核膜（NE）长期以来一直被认为是真核细胞基因组的看门人，仅限制那些能够通过核孔复合物（NPC）穿过NE的分子进入基因组。然而，越来越明显的是，NE 除了提供简单的 DMA 划分之外，还在基因组组织中发挥着积极和重要的作用。 NE 相关复合物对于维持染色质结构、基因调控和 DMA 复制非常重要。 NE 结构的破坏可能导致这些过程的失调。该提案重点关注 NE 膜蛋白在维持 NE 提供的结构完整性方面的作用，特别关注 NE 膜蛋白的跨膜 (TM) 和腔域的作用。