FMRI STUDIES OF AMYGDALA RESPONSE TO FACIAL EXPRESSIONS

杏仁核对面部表情反应的 FMRI 研究

• 批准号: 7197280
• 负责人: PAUL J WHALEN
• 金额: $ 25.84万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7197280
• 关键词: adolescence (12-20); amygdala; behavior test; behavioral /social science research tag; brain electrical activity; clinical research; emotions; face expression; fear; functional magnetic resonance imaging; human subject; neuroimaging; psychopathology; startle reaction; young adult human (21-34)

To date, human neuroimaging studies have offered important insights into amygdala function using facial expressions of emotion as presented stimuli. Our aim is to augment these initial studies by concentrating our efforts on data collection strategies that will provide information about our individual subjects. Specifically, we will use functional magnetic resonance imaging (fHRI) to test the hypothesis that subjective ratings of ambiguously-valenced facial expressions can be used to predict amygdala response to these expressions as well as to more clearly negative faces (e.g., fearful faces). In addition to amygdala responsivity, we will collect additional measures aimed at more comprehensively defining the psychological profile of subjects who rate facial expressions positively vs. negatively. In addition, we will assess the reliability of our measures by assessing both amygdala fMRI response and valence ratings at three separate time points (within-subject). Finally, the project culminates with a collaboration with the Essex Project V in assessing amygdala signal as it relates to our valence rating task, in a group of 72 well characterized adolescent subjects with varying risk for internalizing problems, and thus dsk for psychopathology. Parallel offline behavioral studies that will determine the generalizability of our task. These offline studies will be cdtical in determining the applicability of this task for future field studies. The proposed studies build upon the work of our laboratory and that of others demonstrating that fMRI tasks involving the presentation of facial expressions can provide useful information about normal amygdala function and its aberrance in psychopathology. These studies will provide much needed data concerning a) individual subject differences in these responses b) the generalizability of these data to adolescents and c) the relationship of these measures with others related to vulnerability to psychopathology.

迄今为止，人类神经影像学研究提供了对杏仁核功能的重要见解。我们的目的是通过将精力集中在数据收集策略上，以提供有关我们个人主题的信息，从而增强这些最初的研究。具体而言，我们将使用功能性磁共振成像（FHRI）来检验以下假设：可以使用模棱两可的面部表达式的主观评分来预测杏仁核对这些表达式的响应以及更明显的负面面孔（例如，可怕的面孔）。除了杏仁核反应性外，我们还将收集旨在更全面地定义对面部表情对面部表情的受试者的心理概况的其他措施，这些措施对面部表情的评价为正面和负面影响。此外，我们将通过在三个单独的时间点（受试者内）评估杏仁核FMRI响应和价评级来评估措施的可靠性。最后，该项目与Essex Project V合作评估与我们的价评级任务相关的杏仁核信号，这是在72个具有不同特征的青少年受试者中具有不同风险内在化问题的风险，因此DSK的人的dsk中的DSK。平行的离线行为研究将 确定我们任务的普遍性。这些离线研究将在确定此任务在未来现场研究中的适用性方面具有CD分。拟议的研究基于我们的实验室的工作以及其他人的工作，证明涉及面部表情呈现的fMRI任务可以提供有关正常杏仁核功能及其在心理病理学中的畸变的有用信息。这些研究将提供有关a）这些反应中的个人主题差异的急需数据b）这些数据对青少年的普遍性以及c）这些措施与与精神病理学脆弱性有关的其他措施的关系。