NICHD Cooperative Multicenter Neonatal Research Network

NICHD 多中心新生儿合作研究网络

• 批准号: 7106839
• 负责人: RONALD GOLDBERG
• 金额: $ 41.42万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-05-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7106839
• 关键词: clinical research; clinical trials; cooperative study; disease /disorder proneness /risk; health care facility information system; human subject; human therapy evaluation; low birth weight infant human; mother /infant health care; neonatal intensive care; newborn human (0-6 weeks); obstetrics; patient oriented research; pediatric nursing; pediatrics; perinatal; pregnancy disorder; premature infant human; prenatal care; prenatal diagnosis

DESCRIPTION (provided by applicant): The Division of Neonatology, Duke University School of Medicine enthusiastically submits this renewal application for continued participation in the NICHD-sponsored Cooperative Multicenter Neonatal Research Network (NRN). The NRN's purpose is to investigate treatment strategies for the care neonates through large multicenter collaborative trials. The Division's commitment to NRN research is reflected in its participation in studies, recruitment and follow-up of patients, and its submission and NRN acceptance of projects involving five Duke faculty members. These studies encompass collaborations with other Duke investigators in Infectious Diseases, Mycology, the Pratt School of Engineering and the Center for Human Genetics. These studies include: The Anonymized DNA Bank and Linked Database; Early Diagnosis of Neonatal Candidiasis; Prevalence of APOE in Infants with Perinatal Asyphxia and Intraventricular Hemorrhage; and Gastroesophageal Reflux: Neonatal Network Practices. Duke has participated in the following Network trials: Phototherapy; Body-Cooling for Perinatal Asphyxia; SUPPORT; PCV-7 Immunogenicity; Benchmarking Intervention to Increase Survival without Bronchopulmonary Dysplasia; the Survey of Morbidity and Mortality among VLBW Infants; aEEG to Predict Outcome after Hypoxic-lschemic Encephalopathy; Inositol and Prevention of ROP Pilot, and the Cytokine Studies. Prior to joining the Network, Duke faculty participated in the NICHD-sponsored High Frequency Oscillation Trial and iNO for Prevention of BPD in Premies; and the industry-sponsored CINRGI iNO Study for Term Infants with Pulmonary Hypertension and Head-Cooling for Perinatal Asphyxia studies. The Division of Neonatal-Perinatal Medicine is committed to clinical research and has the School of Medicine's support as evidenced by its receipt of the Duke Translational Medicine Award. Further evidence of our commitment and expertise is illustrated by the participation of faculty in the NRN who are Masters (Gotten, Herrera) and PhD (Benjamin) prepared in clinical research and epidemiology. Significantly, Duke Neonatology's patient catchment area has grown by 56% in the past year and as a consequence is targeted to increase admissions of patients eligible for NRN studies by 25%. The Division houses a comprehensive multidisciplinary follow-up clinic that approaches the patient in a holistic manner with special attention to nutrition. It works collaboratively with community agencies and services and has a patient return rate for Network studies and the Generic Data Base of 3 80%.

描述（由申请人提供）：杜克大学医学院新生儿学系热情地提交了此更新申请，以继续参加NICHD赞助的合作合作多中心新生儿研究网络（NRN）。 NRN的目的是通过大型多中心协作试验调查护理新生儿的治疗策略。该部门对NRN研究的承诺反映在其参与患者的研究，招募和随访以及涉及五名杜克大学教职员工的项目中。这些研究涵盖了与其他杜克大学传染病，真菌学，普拉特工程学院和人类遗传学中心的合作。这些研究包括：匿名DNA库和链接的数据库；新生儿念珠菌病的早期诊断；围产期亚氏症和脑室室内出血的婴儿APOE的患病率；和胃食管反流：新生儿网络实践。杜克大学参加了以下网络试验：光疗；围产期窒息的身体冷却；支持; PCV-7免疫原性；基准测试干预措施以增加没有支气管肺发育不良的生存期； VLBW婴儿中发病率和死亡率的调查； AEEG预测缺氧性肺炎脑病后的结果；肌醇和预防ROP试验和细胞因子研究。在加入网络之前，杜克大学参加了NICHD赞助的高频振荡试验和INO，以防止首映中的BPD。以及行业赞助的CINRGI INO研究，针对肺部高血压和头部冷却性窒息研究的术语婴儿。新生儿 - 耕地医学部致力于临床研究，并获得了医学院的支持，从而获得了杜克翻译医学奖。在临床研究和流行病学领域准备的NRN（Gotten，Herrera）和PhD（Benjamin）的NRN参与来说明了我们承诺和专业知识的进一步证据。值得注意的是，在过去的一年中，杜克新生儿学的患者集水区已增长56％，因​​此，旨在将符合NRN研究的患者入院增加25％。该部门设有一个全面的多学科随访诊所，以整体方式接近患者，并特别关注营养。它与社区机构和服务合作，具有网络研究的患者回报率，通用数据库为3 80％。