Colorado CADDRE: A Case-Cohort Study

科罗拉多州 CADDRE：案例队列研究

• 批准号: 7225741
• 负责人: LISA Ann MILLER
• 金额: $ 107.48万
• 依托单位: COLORADO STATE DEPT/PUB HLTH & ENVIRONMT
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-30 至 2011-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7225741
• 关键词: autism; behavioral /social science research tag; clinical research; comorbidity; cooperative study; developmental disease /disorder; early experience; human subject; infant human (0-1 year); longitudinal human study; mental health epidemiology; preschool child (1-5)

DESCRIPTION (provided by applicant): Autism Spectrum Disorders (ASD) are severe, life-long neurodevelopmental disorders that confer considerable impairment to individuals as well as a substantial burden to their families. Little is known about the prevalence or correlates of ASDs. Little high quality information is available regarding the phenotypic variation among individuals with ASDs, prevalence of co-morbid conditions, and risk factors that might be related to the development of ASDs. The Centers for Autism and Developmental Disabilities Research and Epidemiology were established in 2001 to investigate causes and correlates of autism. The focus of this second funding cycle is to conduct a multi-site collaborative epidemiologic study to investigate risk and causal factors for Autism Spectrum Disorders (ASDs) and phenotypic subgroups of ASDs using a population-based case-cohort study design. Six sites (California, Maryland, North Carolina, Pennsylvania, Colorado, and Georgia) will collaborate to enroll 2700 children and their families over the 5-year study period. Each site will include approximately 150 children with ASD, 150 with other neurodevelopmental disorders, and 150 general population controls to address specific hypotheses in six broad domains: 1) phenotypic variation in ASD, including the pattern of clustering of core symptoms, timing of onset, cognitive status, and presence of medical and psychiatric co- morbidities; 2) gastrointestinal features that may be associated with ASD, 3) candidate genes and genetic variation among individuals with ASD. and how they interact with environmental risk factors, 4) potential for parental infection, immune function, and autoimmunity to be associated with increased ASD risk, 5) potential for parental hormonal and reproductive characteristics to be associated with increased ASD risk, and 6) potential for sociodemographic and lifestyle factors to be associated with increased ASD risk. To address these goals, this study will conduct developmental assessments on the children and collect extensive data on the pre- and perinatal health and environment of the children and their parents via interviews, medical record review, and the collection of biologic samples. This large study of ASD will improve our understanding of how autism differs phenotypically from other disabilities and from typical development. It will also help identify potential risk factors for autism that deserve more attention.

描述（由申请人提供）：自闭症谱系障碍（ASD）是严重的，终生的神经发育障碍，给个人带来了很大的损害，并给家人带来了重大负担。关于ASD的患病率或相关性知之甚少。关于ASD的个体之间的表型变异，合并症状况的流行以及可能与ASDS发展有关的风险因素，几乎没有高质量的信息。自闭症和发育障碍中心研究和流行病学是在2001年建立的，以调查自闭症的原因和相关性。第二个融资周期的重点是进行多站点的协作流行病学研究，以研究自闭症谱系障碍（ASD）（ASD）和ASDS的表型亚组的风险和因果因素，并使用基于人群的病例 - 核心研究设计设计。六个地点（加利福尼亚州，马里兰州，北卡罗来纳州，宾夕法尼亚州，科罗拉多州和佐治亚州）将在5年的研究期内合作招募2700名儿童及其家人。每个站点将包括大约150名ASD儿童，150名患有其他神经发育障碍的儿童和150个普通人群控制，以解决六个广泛领域的特定假设：1）ASD的表型变化，包括核心症状的聚类模式，发病时机，认知状态，以及医学和精神上的co- co co-的存在； 2）可能与ASD相关的胃肠道特征，3）候选基因和ASD个体之间的遗传变异。以及它们如何与环境风险因素相互作用，4）可能与ASD风险增加相关的父母感染，免疫功能和自身免疫性，5）父母荷尔蒙和生殖特征的潜力与ASD风险增加相关，而6）6））社会人口统计学和生活方式因素与ASD风险增加有关。为了解决这些目标，这项研究将对儿童进行发展评估，并通过访谈，病历审查和生物样品收集，收集有关儿童及其父母的前和围产期健康和环境的大量数据。对ASD的这项大型研究将提高我们对自闭症与其他残疾和典型发展的表现差异的理解。它还将有助于确定应受到更多关注的自闭症的潜在危险因素。