Enhancing plant growth with novel catalytic "fertiliser" targeted towards the highly inefficient enzyme Rubisco

利用针对效率极低的 Rubisco 酶的新型催化“肥料”促进植物生长

• 批准号: 2755354
• 金额: --
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2755354
• 关键词: Enhancing; plant; growth; novel; catalytic

Explore a new paradigm targeted towards the global challenge of food security, capitalising upon recent breakthroughs at ICL and will involve an exciting mix of synthetic inorganic and organic chemistry, chemical biology and enzymology. Bringing together expertise from the supervisory team at ICL & Syngenta in (i) photosynthesis, (ii) crop enhancement, (iii) agrochemical physical chemical testing / design / synthesis cycles and (iv) synthetic & formulation chemistry, this studentship will design, synthesise, test and optimise (in an iterative manner) novel molecular CO2 delivery vehicles, and demonstrate their potential as viable, scalable & cost-effective tools able to supercharge photosynthesis in vivo, resulting in increased crop yield.Key features will be (i) the development & optimization of a suite of bio-mimetics able to convert bicarbonate into CO2, (ii) the demonstration of the mimics' ability to improve Rubisco activity in vitro and (iii) in vivo studies using model plants to test their effect on yield.

利用 ICL 最近的突破，探索针对全球粮食安全挑战的新范式，并将涉及合成无机和有机化学、化学生物学和酶学的令人兴奋的组合。该奖学金汇集了 ICL 和先正达监督团队在 (i) 光合作用、(ii) 作物改良、(iii) 农业化学物理化学测试/设计/合成周期和 (iv) 合成和配方化学方面的专业知识，将设计、合成、测试和优化（以迭代方式）新型分子二氧化碳输送载体，并展示其作为可行、可扩展且具有成本效益的工具的潜力，能够增强体内光合作用，从而提高作物产量。主要特点是（i）开发和优化一套能够将碳酸氢盐转化为二氧化碳的生物模拟物，(ii) 证明模拟物在体外提高 Rubisco 活性的能力，以及 (iii) 使用模型植物进行体内研究以测试其对产量的影响。