CCD detector

CCD探测器

• 批准号: 6876881
• 负责人: Carol Muehleman
• 金额: $ 10.17万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-02-01 至 2006-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6876881
• 关键词: articular cartilage; bioimaging /biomedical imaging; biomedical equipment purchase; charge coupled device camera; digital imaging; musculoskeletal imaging /visualization /scanning; noninvasive diagnosis; osteoarthritis

DESCRIPTION (provided by applicant): The assessment of the degree of cartilage degeneration in degenerative joint disease can only be carried out through the invasive technique of arthroscopy, or to a limited extent through Magnetic Resonance Imaging. Although particular cartilage is invisible with conventional radiography, we have previously shown that a novel radiography technique called Diffraction Enhanced X-ray Imaging (DEI) allows the visualization of cartilage and other soft tissues. The goal of this project is to increase the resolution and efficiency of the DEI set-up at the National Synchrotron Light Source of Brookhaven National Laboratory by the replacement of its current image detector in order to increase imaging quality. Currently, there are several medically-oriented X-ray imaging projects underway at the facility, including an NIH Bioengineering Research Partnership dedicated to the imaging of the particular cartilage disease. A new, higher resolution detector will be purchased and installed so as to attain the best possible images for diagnosis of pathology and the determination of the capabilities of the DEI technique under optimal technological conditions. Since the laboratory is already a multi-user facility, the addition of a higher resolution detector will allow each of the present users to attain data of higher quality and with greater information than is currently attainable at the present site. Furthermore, optimization of the technique will facilitate its use by other investigators requiring an imaging resolution high enough for cartilage substructure and small animal joints. DEI technology is now being adopted as a research tool around the world. Thus, with growing competition at European, Asian, and Canadian DEI imaging sites that are already equipped with higher resolution detectors than that at the NSLS facility, the NSLS users are both at a competitive disadvantage as well as incapable of producing the highest quality images that are technologically feasible. Additionally, the optimized facility will greatly enhance the productivity of each user group as a consequence of detector efficiency.

描述（由申请人提供）： 退行性关节疾病中软骨退变程度的评估只能通过关节镜的侵入性技术进行，或者在有限程度上通过磁共振成像进行。尽管传统放射线照相术无法看到特定的软骨，但我们之前已经证明，一种称为衍射增强 X 射线成像 (DEI) 的新型放射线照相技术可以使软骨和其他软组织可视化。该项目的目标是通过更换现有的图像探测器来提高布鲁克海文国家实验室国家同步加速器光源 DEI 装置的分辨率和效率，以提高成像质量。目前，该设施正在进行多个以医学为导向的 X 射线成像项目，其中包括致力于特定软骨疾病成像的 NIH 生物工程研究合作伙伴关系。将购买并安装一台新的、更高分辨率的探测器，以便在最佳技术条件下获得用于病理诊断和确定 DEI 技术能力的最佳图像。由于实验室已经是一个多用户设施，添加更高分辨率的探测器将使每个当前用户能够获得比当前站点当前可获得的更高质量的数据和更多的信息。此外，该技术的优化将有助于其他需要软骨亚结构和小动物关节成像分辨率足够高的研究人员使用它。 DEI 技术现已被世界各地采用作为一种研究工具。因此，随着欧洲、亚洲和加拿大 DEI 成像站点的竞争日益激烈，这些站点已经配备了比 NSLS 设施更高分辨率的探测器，NSLS 用户既处于竞争劣势，又无法生成最高质量的图像，因此技术上是可行的。此外，优化的设施将由于探测器效率而大大提高每个用户组的生产力。