DYNAMIC DETERMINANTS OF EXCEPTIONAL HEALTH AT LATE AGES

晚年健康状况的动态决定因素

• 批准号: 7008438
• 负责人: ANATOLIY I YASHIN
• 金额: $ 34.32万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-02-15 至 2009-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7008438
• 关键词: aging; clinical research; computer simulation; disease /disorder proneness /risk; functional ability; human data; long term survivor; longevity; longitudinal human study; mathematical model; model design /development; outcomes research

DESCRIPTION (provided by applicant): The broad long-term objectives of the proposed research are evaluation of the role of age trajectories of physiological indices as well as other factors as determinants of exceptional health among the elderly, by combining data collected in different longitudinal studies. Specific aims: 1. Evaluate effects of age trajectories of each of the selected physiological indices, as well as other factors measured in Framingham Heart Study (FHS), Framingham Offspring Study (FHSO) and Honolulu Heart Study (HHS), on exceptional health among the elderly using traditional statistical methods. Evaluate changes in the effects of risk factors with age. 2. Develop mathematical and computer models describing mechanisms generating age dynamics of each physiological index including possibility of their homeostatic regulation and dynamic connection to health outcomes. Use these models in the analysis of FHS, HHS and FHSO data to: a) evaluate age related changes in coefficients of homeostatic regulation with age in each of selected physiological indices and their role in healthy aging; b) evaluate changes in the role of each index in determining health outcomes with age. 3. Evaluate age-related changes in characteristics determining joint dynamics of a set of selected physiological indices, as well as changes in effects of these indices on health outcomes. Evaluate age trajectories of "normal" or "optimal" physiological state as well as the range of tolerable deviations from it. For this purpose develop mathematical and computer model describing joint age dynamics of a set of physiological indices and its connection to health outcomes. Use this model in the analysis of FHS, FHSO and HHS data to address issues formulated above. 4. Evaluate dynamic determinants of exceptional health at late ages in the joint analysis of FHS, FHSO and HHS data. For this purpose develop compatible mathematical and computer models describing joint dynamics of a set of selected physiological indices and their connection to health outcomes for each of three selected data sets and use these models in joint analysis of these three longitudinal data sets. Evaluate differences and similarities in dynamic determinants of exceptional health at late ages in populations participating in joint analysis of data. Evaluate contribution of genetic and non-genetic factors in exceptional health at late ages in the joint analysis of FHS and FHSO data.

描述（由申请人提供）：拟议研究的广泛长期目标是通过结合不同纵向研究中收集的数据来评估生理指标的年龄轨迹以及其他因素作为老年人异常健康的决定因素的作用。具体目标： 1. 评估每个选定生理指标的年龄轨迹以及弗雷明汉心脏研究 (FHS)、弗雷明汉后代研究 (FHSO) 和檀香山心脏研究 (HHS) 中测量的其他因素对异常健康状况的影响老年人使用传统的统计方法。评估危险因素影响随年龄的变化。 2. 开发数学和计算机模型，描述产生每个生理指标年龄动态的机制，包括其稳态调节的可能性以及与健康结果的动态联系。在 FHS、HHS 和 FHSO 数据分析中使用这些模型来： a) 评估每个选定的生理指标中稳态调节系数随年龄的年龄相关变化及其在健康老龄化中的作用； b) 评估每个指标在确定健康结果方面的作用随年龄的变化。 3. 评估决定一组选定生理指标关节动态的特征与年龄相关的变化，以及这些指标对健康结果影响的变化。评估“正常”或“最佳”生理状态的年龄轨迹以及可容忍的偏差范围。为此目的，开发数学和计算机模型，描述一组生理指标的联合年龄动态及其与健康结果的联系。使用此模型分析 FHS、FHSO 和 HHS 数据来解决上述问题。 4. 联合分析 FHS、FHSO 和 HHS 数据，评估晚年异常健康的动态决定因素。为此，开发兼容的数学和计算机模型，描述一组选定的生理指标的联合动态及其与三个选定数据集中每一个的健康结果的联系，并使用这些模型对这三个纵向数据集进行联合分析。评估参与数据联合分析的人群晚年异常健康的动态决定因素的差异和相似之处。通过 FHS 和 FHSO 数据的联合分析，评估遗传和非遗传因素对晚年异常健康的贡献。