DYNAMIC DETERMINANTS OF EXCEPTIONAL HEALTH AT LATE AGES

晚年健康状况的动态决定因素

• 批准号: 7008438
• 负责人: ANATOLIY I YASHIN
• 金额: $ 34.32万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-02-15 至 2009-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7008438
• 关键词: aging; clinical research; computer simulation; disease /disorder proneness /risk; functional ability; human data; long term survivor; longevity; longitudinal human study; mathematical model; model design /development; outcomes research

DESCRIPTION (provided by applicant): The broad long-term objectives of the proposed research are evaluation of the role of age trajectories of physiological indices as well as other factors as determinants of exceptional health among the elderly, by combining data collected in different longitudinal studies. Specific aims: 1. Evaluate effects of age trajectories of each of the selected physiological indices, as well as other factors measured in Framingham Heart Study (FHS), Framingham Offspring Study (FHSO) and Honolulu Heart Study (HHS), on exceptional health among the elderly using traditional statistical methods. Evaluate changes in the effects of risk factors with age. 2. Develop mathematical and computer models describing mechanisms generating age dynamics of each physiological index including possibility of their homeostatic regulation and dynamic connection to health outcomes. Use these models in the analysis of FHS, HHS and FHSO data to: a) evaluate age related changes in coefficients of homeostatic regulation with age in each of selected physiological indices and their role in healthy aging; b) evaluate changes in the role of each index in determining health outcomes with age. 3. Evaluate age-related changes in characteristics determining joint dynamics of a set of selected physiological indices, as well as changes in effects of these indices on health outcomes. Evaluate age trajectories of "normal" or "optimal" physiological state as well as the range of tolerable deviations from it. For this purpose develop mathematical and computer model describing joint age dynamics of a set of physiological indices and its connection to health outcomes. Use this model in the analysis of FHS, FHSO and HHS data to address issues formulated above. 4. Evaluate dynamic determinants of exceptional health at late ages in the joint analysis of FHS, FHSO and HHS data. For this purpose develop compatible mathematical and computer models describing joint dynamics of a set of selected physiological indices and their connection to health outcomes for each of three selected data sets and use these models in joint analysis of these three longitudinal data sets. Evaluate differences and similarities in dynamic determinants of exceptional health at late ages in populations participating in joint analysis of data. Evaluate contribution of genetic and non-genetic factors in exceptional health at late ages in the joint analysis of FHS and FHSO data.

描述（由申请人提供）：拟议的研究的广泛长期目标是评估生理指数年龄轨迹的作用以及其他因素作为老年人在不同纵向研究中收集的数据中的特殊健康决定因素。具体目的：1。评估每个选定的生理指标的年龄轨迹的影响，以及在弗雷明汉心脏研究（FHS），弗雷明汉·后代研究（FHSO）和檀香山心脏研究（HHS）（HHS）中测得的其他因素，对使用传统统计学的老年人对特殊健康的影响。评估风险因素随年龄的影响的变化。 2。开发数学和计算机模型，描述了生成每个生理指数年龄动态的机制，包括其稳态调节的可能性以及与健康结果的动态连接。在对FHS，HHS和FHSO数据的分析中，使用这些模型来：a）评估年龄相关的稳态调节系数随着年龄的年龄而在每个选定的生理指标中及其在健康衰老中的作用； b）评估每个指数在确定年龄段确定健康结果中的作用的变化。 3。评估与年龄相关的特征变化，确定一组选定的生理指标的关节动力学，以及这些指数对健康结果的影响的变化。评估“正常”或“最佳”生理状态的年龄轨迹以及与之可忍受的偏差范围。为此，开发了数学和计算机模型，描述了一组生理指标的关节年龄动态及其与健康结果的联系。在FHS，FHSO和HHS数据的分析中使用此模型来解决上述问题。 4。在FHS，FHSO和HHS数据的联合分析中评估晚年晚期特殊健康的动态决定因素。为此，开发了兼容的数学和计算机模型，描述了一组选定的生理指标的联合动力学及其与三个选定数据集的每个数据集的联系，并在对这三个纵向数据集的联合分析中使用这些模型。评估参与数据联合分析的人群中特殊健康的动态决定因素的差异和相似性。在FHS和FHSO数据的联合分析中，评估遗传和非遗传因素在特殊健康中的贡献。