Lifespan Effects of Choline on Neurogenesis and Behavior

胆碱对神经发生和行为的寿命影响

• 批准号: 7228627
• 负责人: MELISSA J GLENN
• 金额: $ 5.04万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-02 至 2008-04-01
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7228627
• 关键词: age difference; aging; animal old age; behavioral /social science research tag; cell differentiation; cell proliferation; choline; cognition; corticosterone; environmental stressor; hippocampus; laboratory rat; learning; mature animal; memory; mother /embryo /fetus nutrition; neural plasticity; neurogenesis; neuroprotectants; nutrition related tag; postdoctoral investigator; stress

DESCRIPTION (provided by candidate): The aim of the proposed work is to examine the hypotheses that prenatal choline supplementation enhances neurogenesis in adult and aged rats, and moderates stress reactivity in adult rats. Choline availability in utero modulates hippocampal cholinergic function and memory in adulthood, and prenatal choline supplementation, specifically, enhances hippocampal function and morphology, and has the extraordinary effect of preventing declines in memory in aged rats. Enhanced and preserved neurogenesis across the lifespan may be one mechanism by which prenatal choline supplementation confers a cognitive advantage to adult and aging rats. Stress reactivity is also established during development and is subject to modification by perinatal environmental factors. Altered HPA function may contribute to choline's positive effects in adulthood and choline may prevent stress' negative effects on aging. Findings consistent with this proposal would be the first to demonstrate that prenatal choline supplementation enhances neurogenesis in adulthood and has the capacity to moderate physiological, behavioral, and neuroanatomical responses to stress.

描述（由候选人提供）：拟议工作的目的是检验以下假设：产前补充胆碱可增强成年和老年大鼠的神经发生，并调节成年大鼠的应激反应性。 子宫内的胆碱可调节海马的胆碱能功能和成年期的记忆力，产前补充胆碱尤其可以增强海马的功能和形态，对预防老年大鼠的记忆力下降具有非凡的效果。 在整个生命周期中增强和保留神经发生可能是产前补充胆碱赋予成年和衰老大鼠认知优势的一种机制。 应激反应性也在发育过程中建立，并受到围产期环境因素的影响。 HPA 功能的改变可能有助于胆碱在成年期发挥积极作用，而胆碱则可能防止压力对衰老产生的负面影响。 与该提议一致的研究结果将首次证明产前补充胆碱可增强成年期的神经发生，并具有调节对压力的生理、行为和神经解剖学反应的能力。