Lifespan Effects of Choline on Neurogenesis and Behavior

胆碱对神经发生和行为的寿命影响

• 批准号: 7234036
• 负责人: MELISSA J GLENN
• 金额: $ 1.85万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-02 至 2007-08-01
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7234036
• 关键词: Acetylcholine; Acute; Adult; Adult Children; Affect; Age; Aging; Alzheimer' s Disease; Animals; Behavior; Behavioral; Birth; Cell Count; Cell Proliferation; Cells; Choline; Cholinergic Agents; Chronic; Cognition; Cognitive; Corticosterone; Data; Dementia; Development; Diet; Disease; Environment; Environmental Risk Factor; Event; Figs - dietary; Goals; HPSE gene; Health; Hippocampus (Brain); Ischemia; Knowledge; Laboratories; Lead; Learning; Link; Longevity; Measures; Mediating; Memory; Mental Depression; Metabolism; Modification; Morphology; Neuronal Plasticity; Neurons; Neurotransmitters; Numbers; Nutrient; Parahippocampal Gyrus; Pathology; Performance; Perinatal; Physiological; Physiology; Rat-1; Rattus; Research; Rodent; Schizophrenia; Source; Stress; Stressful Event; Structure; Supplementation; System; Testing; Training; Work; acute stress; age related; aged; aging hippocampus; basal forebrain; base; cholinergic; cognitive function; dentate gyrus; design; feeding; hypothalamic-pituitary-adrenal axis; improved; in utero; neurochemistry; neurogenesis; novel; prenatal; prevent; relating to nervous system; response; young adult

DESCRIPTION (provided by candidate): The aim of the proposed work is to examine the hypotheses that prenatal choline supplementation enhances neurogenesis in adult and aged rats, and moderates stress reactivity in adult rats. Choline availability in utero modulates hippocampal cholinergic function and memory in adulthood, and prenatal choline supplementation, specifically, enhances hippocampal function and morphology, and has the extraordinary effect of preventing declines in memory in aged rats. Enhanced and preserved neurogenesis across the lifespan may be one mechanism by which prenatal choline supplementation confers a cognitive advantage to adult and aging rats. Stress reactivity is also established during development and is subject to modification by perinatal environmental factors. Altered HPA function may contribute to choline's positive effects in adulthood and choline may prevent stress' negative effects on aging. Findings consistent with this proposal would be the first to demonstrate that prenatal choline supplementation enhances neurogenesis in adulthood and has the capacity to moderate physiological, behavioral, and neuroanatomical responses to stress.

描述（由候选人提供）：拟议的工作的目的是检查假设的假设，即补充产前胆碱可以增强成年大鼠和年龄大鼠的神经发生，并缓解成年大鼠的压力反应性。 子宫内的胆碱可用性调节成年后的海马胆碱能功能和记忆力，并补充产前胆碱，特别是增强了海马功能和形态，并且具有防止年龄大鼠记忆力下降的非凡效果。 在整个生命周期中增强和保存的神经发生可能是一种机制，通过该机制补充产前胆碱对成年大鼠和衰老大鼠具有认知优势。 在开发过程中还建立了应力反应性，并受到围产期环境因素的修改。 HPA功能的改变可能会导致胆碱在成年中的积极作用，而胆碱可能会阻止应激对衰老的负面影响。 与该建议一致的发现将是第一个证明产前胆碱补充剂可以增强成年后神经发生，并且具有适度的生理，行为和神经解剖学对压力的反应。