Multiscale mechanics: folded globular proteins as hydrogel Lego bricks

多尺度力学：折叠球状蛋白质作为水凝胶乐高积木

• 批准号: 2751760
• 金额: --
• 依托单位: University of Leeds
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2751760
• 关键词: Multiscale; mechanics; folded; globular; proteins

Mechanical properties are an essential property of biological scaffolds, where cell behaviour can be controlled by designing material scaffolds that incorporate specific structural and mechanical cues.Proteins are semi-flexible polymer and biopolymer networks formed by semi-flexible polymers have emerged as a new class of biological soft matter systems with remarkable material properties, motivating many theoretical developments. Such theories include the mechanics and dynamics of individual semiflexible polymers, bundles and entangled solutions and non-affine approaches for disordered polymer networks.The PGR will join a multidisciplinary team to understand the physics of the building block (the folded protein) and its connectivity (the protein network). This will be achieved through a cross length scale, physics based approach which will translate knowledge of the nanoscale biophysics of folded proteins to the mesoscale architecture and function of novel folded protein hydrogels. Experimental techniques will include rheology, scattering, microbubbles and ultrasound.

机械性能是生物支架的重要特性，可以通过设计包含特定结构和机械线索的材料脚手脚架来控制细胞行为。蛋白质是半富含的聚合物，由半灵性聚合物形成的生物聚合物网络已成为一种新型的生物软质物质系统与许多出色的材料物质，许多材料的物质，许多旨在发展的材料。这样的理论包括单个半灵性聚合物的力学和动力学，捆绑包和纠缠溶液以及用于无序聚合物网络的非植物方法。PGR将加入一个多学科团队，以了解基础（折叠蛋白）的物理（折叠蛋白）及其连接性（蛋白质网络）。这将通过基于物理学的方法来实现，该方法将把折叠蛋白的纳米级生物物理学转化为新型折叠蛋白水凝胶的中尺度结构和功能。实验技术将包括流变学，散射，微泡和超声波。