Microradiographic Guidance of Flow Modifying Stents

血流改变支架的显微放射学指导

• 批准号: 6802025
• 负责人: STEPHEN RUDIN
• 金额: $ 64.96万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-20 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6802025
• 关键词: X ray; aneurysm; angiography; bioengineering /biomedical engineering; bioimaging /biomedical imaging; biomedical equipment development; blood vessel prosthesis; cerebrovascular imaging /visualization; clinical research; computed axial tomography; dogs; fluoroscopy; human subject; microradiography

DESCRIPTION (provided by applicant): The aim of this project is to build a new very high spatial resolution, rapid frame rate region of interest (ROI) x-ray detector system, the micro-angiographic fluoroscope (MAF) and to use it for guiding and evaluating new stents used for flow modification in the treatment of intracranial aneurysms. The detector due to its large adjustable gain will be capable of acquiring 30 fps at both fluoroscopic exposures in the fractional microR and higher range as well as at angiographic exposures in the mR range. The detector will have adjustable pixel size and be capable of pixel sizes less than 50 mu/m and will have high-contrast spatial resolution greater than 10 lp/mm while operating at typical angiographic kVp's. The MAF will have a viewing field of at least 5 cm diameter sufficient for viewing small regions where interventions and in particular flow modifying interventions are occurring. The MAF will be compatible with existing commercial angiographic x-ray sources and be mounted in such a way as to be interposed between the x-ray image intensifier, X/I, of the commercial system and the phantom, animal, or patient so that the MAF can be used when its high resolution ROI capabilities are needed, usually at critical times during interventional procedures. Additionally, the MAF will be used for cone-beam rotational microangiography and micro-computed tomography (CT) for determining vessel lumens needed for accurate flow assessment. Also, the new imaging capability for accurate localization will allow the development and implementation of new devices: asymmetric, variable porosity stents for treatment of cerebral aneurysms by modifying aneurysm blood flow characteristics. To optimize the new stent design, flow reduction in aneurysms needed to induce thrombosis will be explored. Also details of flow and flow modification will be investigated using advanced theoretical and experimental methods. Finally clinical application of the high-resolution microfluoroscopic detector will be used to evaluate the use of stents for flow modification in the cerebrovasculature of human patients.

描述（由申请人提供）： 该项目的目的是构建一种新的非常高空间分辨率、快速帧速率感兴趣区域 (ROI) X 射线检测器系统、微血管造影荧光镜 (MAF)，并用它来引导和评估用于血管造影的新型支架。血流改变治疗颅内动脉瘤。由于其较大的可调增益，该探测器能够在分数 microR 和更高范围内的荧光镜曝光以及 mR 范围内的血管造影曝光下采集 30 fps 的数据。该探测器将具有可调节的像素尺寸，像素尺寸小于 50 μ/m，并且在典型的血管造影 kVp 下运行时具有大于 10 lp/mm 的高对比度空间分辨率。 MAF 将具有至少 5 厘米直径的视场，足以观察正在发生干预措施（尤其是改变流量干预措施）的小区域。 MAF 将与现有的商业血管造影 X 射线源兼容，并以插入商业系统的 X 射线图像增强器 X/I 和体模、动物或患者之间的方式安装，以便当需要高分辨率 ROI 功能时（通常是在介入手术期间的关键时刻），可以使用 MAF。此外，MAF 将用于锥束旋转微血管造影和微计算机断层扫描 (CT)，以确定精确流量评估所需的血管腔。此外，用于精确定位的新成像能力将允许开发和实施新设备：不对称、可变孔隙率支架，通过改变动脉瘤血流特性来治疗脑动脉瘤。为了优化新支架设计，将探索减少诱导血栓形成所需的动脉瘤流量。还将使用先进的理论和实验方法研究流动和流动修改的细节。最后，高分辨率显微荧光检测器的临床应用将用于评估支架在人类患者脑血管系统中用于血流调节的使用。