Radiographic guidance of new cerebral aneurysm stent

新型脑动脉瘤支架的影像引导

• 批准号: 6729695
• 负责人: STEPHEN RUDIN
• 金额: $ 64.33万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-15 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6729695
• 关键词: blood vessel prosthesis; cerebral aneurysm; clinical research; dogs; fluidity; hemodynamics; hemorrhage; human data; laboratory rabbit; radiography; shear stress; thrombosis

DESCRIPTION (provided by applicant): The limitations of radiographic visualization and the lack of consideration of the influence of stentt deployment on details of blood flow have limited stentt design to forms which are uniform and circularly symmetric. Yet some of the most important potential applications of stents such as in the treatment of aneurysms are inherently non-uniform and non-symmetric in nature. In this project, the design of innovative asymmetric stents and their deployment enabled by guidance with new high resolution x-ray image detectors are investigated. In particular, the limitations and accuracy in localizing the rotational orientation as well as the longitudinal distance of small asymmetric devices delivered by catheters within the vasculature under radiographic guidance are explored for the first time. This new capability for accurate localization will allow the implementation of new devices such as asymmetric, variable porosity stentts for treatment of cerebral aneurysms by modifying aneurysm blood flow characteristics. To optimize the new stentt design, flow reduction in aneurysms needed to induce thrombosis will be explored. Also details of flow and flow modification will be investigated using advanced theoretical and experimental methods. It is expected that this new capability should enable more rapid treatment of aneurysms with less chance of hemorrhage and decreased possibility for recurrence compared with existing procedures and additionally readily enable treatment of wide-necked and giant cerebral aneurysms for the first time.

描述（由申请人提供）： 射线照相可视化的局限性以及缺乏考虑支架展开对血流细节的影响，限制了支架设计为均匀且圆形对称的形式。然而，支架的一些最重要的潜在应用，例如在动脉瘤的治疗中，本质上是不均匀和不对称的。在该项目中，研究了创新型不对称支架的设计及其在新型高分辨率 X 射线图像探测器引导下的部署。特别是，首次探讨了在放射照相引导下定位脉管系统内导管输送的小型不对称装置的旋转方向和纵向距离的局限性和准确性。这种精确定位的新功能将允许实施新设备，例如不对称、可变孔隙率支架，通过改变动脉瘤血流特性来治疗脑动脉瘤。为了优化新支架设计，将探索减少诱导血栓形成所需的动脉瘤流量。还将使用先进的理论和实验方法研究流动和流动修改的细节。预计与现有手术相比，这种新功能将能够更快速地治疗动脉瘤，减少出血机会并降低复发可能性，并且首次能够轻松治疗宽颈和巨大脑动脉瘤。