Center of Predictive Medicine for Biodefense

生物防御预测医学中心

• 批准号: 7005601
• 负责人: WILLIAM M PIERCE
• 金额: $ 2194.52万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7005601
• 关键词: behavioral /social science research tag; biomedical facility; bioterrorism /chemical warfare; building /facility design /renovation; cooperative study; emerging infectious disease; host organism interaction; interdisciplinary collaboration; medicine; proteomics

DESCRIPTION (provided by applicant): The University of Louisville proposes to establish a Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases (CPMBEID). Our long-term objective is to support the development of gene-based countermeasures and diagnostic approaches based on system changes that occur during host-pathogen interactions. Focusing on host-based bio-threat and emerging infectious disease research should allow the development of broad-spectrum interventions to infectious agents rather than the current paradigm of "one bug/one vaccine" approach so prevalent today. Our specific aims are to 1) meet the expanding needs of current researchers who work with Category A, B, or C priority pathogens at the University of Louisville; 2) expand facilities so that we can add an additional six faculty investigators who work with these agents; 3) assemble a unique mix of technologies in a free standing BSL3 facility so that the instrumentation and expertise is available on site to manipulate experimental materials and avoid the need for shipping material off site; and 4) to serve as a resource for investigators from other institutions in our region who can benefit from the unique mix of technologies we will assemble in the facility as well as be prepared to bring those technologies to bear in the event of a bioterrorism emergency. The University created a superb team of investigators and administrators to shepherd this project from application to operation. We are committed to working with NIAID and believe our missions can be mutually reinforced by building a RBL in Louisville.

描述（由申请人提供）： 路易斯维尔大学提议建立一个预测医学中心 生物防御和新发传染病（CPMBEID）。我们的长期目标是支持基于宿主与病原体相互作用期间发生的系统变化的基于基因的对策和诊断方法的开发。重点关注基于宿主的生物威胁和新出现的传染病研究，应该能够开发出针对传染源的广谱干预措施，而不是目前流行的“一种病菌/一种疫苗”方法的范式。我们的具体目标是 1) 满足路易斯维尔大学当前研究 A、B 或 C 类优先病原体的研究人员不断增长的需求； 2）扩大设施，以便我们可以增加六名与这些特工一起工作的教职调查员； 3) 在独立的 BSL3 设施中组装独特的技术组合，以便现场可以使用仪器和专业知识来操作实验材料，并避免将材料运输到场外； 4) 为我们地区其他机构的调查人员提供资源，他们可以从我们将在该设施中组装的独特技术组合中受益，并准备好在发生生物恐怖主义紧急情况时利用这些技术。该大学创建了一支由研究人员和管理人员组成的优秀团队来指导该项目从申请到运营。我们致力于与 NIAID 合作，并相信通过在路易斯维尔建立 RBL 可以相互加强我们的使命。