Advance Technologies

先进技术

• 批准号: 7262334
• 负责人: Nigel Bourne
• 金额: $ 6.77万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-03 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7262334
• 关键词: biomedical facility; bioterrorism /chemical warfare; cooperative study; emerging infectious disease; experimental designs; high throughput technology

The central function of the Advanced Technologies core (ATC) will be to support GNL researchers in translating basic science knowledge and discoveries into practical measures to improve human health. Research undertaken in the GNL will identify many new potential targets for therapeutics and diagnostics against life threatening infectious diseases. In fulfilling its central function the first service that the ATC will provide will be the resources and expertise to develop in vitro assays that utilize such new targets and technologies, from the research bench top to a standardized, reproducible and validated format suitable that can be used in medium to high throughput screening (HTS) studies. Wherever possible the ATC will place emphasis on developing assays that can be conducted under low containment BSL2 conditions which will maximize their subsequent utility to the research community. However, not all assays developed will be suitable for BSL2 use and, effective validation of many of the BSL2 assays will require confirmatory studies using live pathogens under BSL3 or BSL4 containment. Therefore, as part of its in vitro assay development function the core will not only maintain BSL2 containment resources but will have the resources to conduct assay development under BSL3 and BSL4 containment conditions. The second service that the ATC will provide to the GNL will be infrastructure to conduct HTS studies using the assays that it develops, or other already existing assays under both BSL2 and BSL3 containment with the additional capacity to conduct small scale studies under BSL4 containment. This screening program will provide GNL researchers with the ability to identify active compounds to serve as leads for development of potential new therapeutics. The third major service of the ATC will be to coordinate interactions between GNL researchers and those resources and expertise in specialized research cores that already exist on the UTMB campus. In this role the ATC will contribute directly to the cost effective running of the GNL in two distinct ways. Firstly, it will ensure that GNL researchers make full use of existing resources rather than duplicating them and, secondly, it will minimize the time and effort involved in individual researchers accessing these resources on an ad hoc basis by acting as a single source point of access. This will directly increase research efficiency for the GNL.

高级技术核心（ATC）的核心功能是支持G​​NL研究人员 将基础科学知识和发现转化为改善人类健康的实用措施。 在GNL中进行的研究将确定许多用于治疗和诊断的新潜在目标 反对威胁生命的传染病。在履行其中心功能时，ATC将 提供的资源和专业知识将是开发利用此类新目标的体外测定法和专业知识 从研究台上到标准化，可重现和经过验证的格式，技术 可用于中等到高吞吐量筛查（HTS）研究。尽可能地将ATC放置 强调开发可以在低遏制BSL2条件下进行的测定 最大化他们随后对研究界的效用。但是，并非所有开发的分析都会是 适用于BSL2使用和有效验证许多BSL2测定法将需要确认性研究 在BSL3或BSL4遏制下使用活病原体。因此，作为其体外测定开发的一部分 功能核心不仅将维护BSL2遏制资源，而且还将有资源进行 BSL3和BSL4遏制条件下的测定开发。 ATC将向GNL提供的第二项服务将是使用HTS研究的基础架构 它开发的测定法或BSL2和BSL3遏制下的其他已经存在的测定法 在BSL4遏制下进行小规模研究的额外能力。这个筛选计划将 为GNL研究人员提供识别活性化合物的能力，以作为开发的铅 潜在的新治疗学。 ATC的第三个主要服务是协调GNL研究人员与那些人之间的互动 UTMB校园已经存在的专业研究核心的资源和专业知识。在这个角色中 ATC将以两种不同的方式直接为GNL的成本效益运行做出贡献。首先，它会 确保GNL研究人员充分利用现有资源，而不是复制它们，并 其次，它将最大程度地减少个人研究人员访问这些资源的时间和精力 通过充当单个访问点的临时基础。这将直接提高研究效率 对于GNL。