Sensory Processing Deficits in Cannabis Use

大麻使用中的感官处理缺陷

• 批准号: 7126349
• 负责人: PATRICK David SKOSNIK
• 金额: $ 7.4万
• 依托单位: TRUSTEES OF INDIANA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7126349
• 关键词: auditory stimulus; behavioral /social science research tag; clinical research; drug detection; electroencephalography; evoked potentials; human subject; interview; marijuana abuse; neural information processing; perceptual distortions; personality; psychometrics; psychopharmacology; questionnaires; substance abuse related behavior; visual stimulus

DESCRIPTION (provided by applicant): It is well known that use of the drug cannabis can induce subjective distortions of perception in several sensory modalities. However, few direct examinations of the neural effects of cannabis use on early sensory processing have been undertaken, particularly utilizing novel electrophysiological techniques. The overall aim of the current proposal is to examine whether current cannabis users demonstrate deficits in neural synchronization as measured by electroencephalographic (EEG) entrainment to periodic auditory and visual stimulation. Subjects will passively observe periodic sensory stimuli (auditory click-trains (10, 20, 30, 40, and 50 Hz) and photic flickers (8, 13, 18, 25, and 38 Hz) while EEGs are recorded. The ability of the resulting steady-state potentials to synchronize to the specific frequencies of stimulation will be assessed via EEG power, signal to noise ratio, and intertrial coherence. In addition, EEG synchronization during perceptual binding will be assessed utilizing an induced gamma paradigm (moving dot stimuli using Random Dot Kinetograms). Several clinical interviews and psychometric questionnaires will also be administered in order to determine possible relationships between EEG brain measures and the perceptual correlates of cannabis use. It is hypothesized that during the entrainment paradigms cannabis users will exhibit decreased EEG power, signal to noise ratio, and intertrial coherence at the frequencies of stimulation across sensory modalities. It is also predicted that during the induced EEG paradigm, cannabis users will exhibit decreased gamma-band (~ 40 Hz) activity during the perception of coherent moving dots. It is hypothesized that these deficits in EEG neural synchronization will correlate with psychometric measures such as schizotypal personality and perceptual aberration, as well as urinary measures of cannabis metabolites. Taken together, this data may serve to elucidate whether the known cognitive dysfunction observed in cannabis use is in part related to disturbances in early sensory information processing and/or neural synchronization.

描述（由申请人提供）：众所周知，使用药物大麻可以在几种感觉方式中诱发主观的感知扭曲。但是，很少有关于大麻使用对早期感觉处理的神经影响的直接检查，尤其是利用新型的电生理技术。当前提案的总体目的是检查当前的大麻使用者是否表现出通过脑脑摄影（EEG）夹带的介入对周期性听觉和视觉刺激的夹带衡量的神经同步缺陷。 Subjects will passively observe periodic sensory stimuli (auditory click-trains (10, 20, 30, 40, and 50 Hz) and photic flickers (8, 13, 18, 25, and 38 Hz) while EEGs are recorded. The ability of the resulting steady-state potentials to synchronize to the specific frequencies of stimulation will be assessed via EEG power, signal to noise ratio, and intertrial coherence. In addition, EEG在感知结合期间，将使用诱导的γ范式评估感知结合（使用随机的DOT动力学图）进行了几个临床访谈，并且心理测量调查表也将施用，以确定EEG脑测量的可能性，以确定eeg脑的使用量。功率，信号与噪声比和跨感觉方式刺激频率的内部连贯性。还可以预测，在诱导的EEG范式中，大麻使用者将在相干移动点的感知期间表现出降低的伽玛频段（约40 Hz）活性。假设EEG神经同步中的这些缺陷将与心理测量指标（如精神型人格和感知畸变）以及大麻代谢产物的尿量指标相关。综上所述，这些数据可以阐明大麻使用中观察到的已知认知功能障碍是否与早期感觉信息处理和/或神经同步中的扰动有关。

项目成果

Disrupted gamma-band neural oscillations during coherent motion perception in heavy cannabis users.

重度大麻使用者的连贯运动感知过程中伽马带神经振荡被破坏。

• DOI: 10.1038/npp.2014.166
• 发表时间: 2014
• 期刊: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
• 作者: Skosnik,PatrickD;Krishnan,GiriP;D'Souza,DeepakC;Hetrick,WilliamP;O'Donnell,BrianF
• 通讯作者: O'Donnell,BrianF

The effect of chronic cannabinoids on broadband EEG neural oscillations in humans.

慢性大麻素对人类宽带脑电图神经振荡的影响。

• DOI: 10.1038/npp.2012.65
• 发表时间: 2012
• 期刊: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
• 作者: Skosnik,PatrickD;D'Souza,DeepakC;Steinmetz,AdamB;Edwards,ChadR;Vollmer,JenniferM;Hetrick,WilliamP;O'Donnell,BrianF
• 通讯作者: O'Donnell,BrianF