HRQL Impact of Chronic Conditions and Comorbidity Burden

慢性病和合并症负担的 HRQL 影响

• 批准号: 7016561
• 负责人: PATRICK W SULLIVAN
• 金额: $ 6.93万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-15 至 2008-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7016561
• 关键词: aging; behavioral /social science research tag; chronic disease /disorder; comorbidity; cost effectiveness; data collection methodology /evaluation; health care cost /financing; health care service evaluation; health care service planning; health economics; health services research tag; health surveys; human data; psychometrics; quality of life; statistics /biometry

DESCRIPTION (provided by applicant): As life expectancy has increased for the average American, attention is focused on improving health-related quality of life (HRQL). The burgeoning cost of medical care within the reality of limited societal resources has necessitated the use of cost-effectiveness methods to assess the value of competing health interventions for an aging population. Quality-adjusted life years (QALYs) rely on preference weights to adjust the HRQL of different health states: Preference weights are the cornerstone of the QALY method, and are integral to the appropriate use of cost-effectiveness analysis. The Panel on Cost-Effectiveness in Health and Medicine (PCEHM) has called for a catalogue of "off the shelf preference weights associated with conditions that could be used by health researchers to promote the comparability of cost-effectiveness analyses in the U.S., thereby enabling accurate assessment of the medical interventions with the most value for the treatment of chronic conditions in older populations. Sullivan et al. have developed a preliminary catalogue of preference weights for chronic conditions, incorporating a generic examination of comorbidity burden and age. The overall objective of the current application is to 1) increase the depth of the catalogue for select priority conditions affecting older adults by assessing more specifically the impact of age, chronic disease and comorbidity interactions and 2) increase the breadth of the catalogue by examining EQ-5D index scores associated with an additional 293 chronic ICD-9 codes. We plan to accomplish the overall objective of this application by linking several publicly available data files and pursuing the following specific aims in the resultant nationally representative sample of the U.S. population: 1) determine the most prevalent comorbidities associated with select chronic conditions impacting older adults; 2) assess the impact of chronic conditions, comorbidity interactions and age on preference-based HRQL scores for select chronic conditions impacting older adults and 3) develop preference weights for chronic ICD-9 codes in the U.S.

描述（由申请人提供）：随着普通美国人的预期寿命增加，注意力集中在改善与健康相关的生活质量（HRQL）上。在有限的社会资源现实中，医疗护理的迅速成本已经需要使用成本效益方法来评估对老龄化人群的竞争健康干预措施的价值。质量调整后的寿命（QALYS）依靠偏好权重调整不同健康状态的HRQL：偏好权重是QALY方法的基石，并且是适当使用成本效益分析的组成部分。关于健康和医学成本效益（PCEHM）的成本效益小组呼吁进行“与健康研究人员可以使用的条件相关的货架偏好权重目录，以促进美国的成本效益分析的可比性，从而可以对医疗条件进行准确评估的最大程度的评估，从而对较高的状况进行了较高的治疗。对于慢性病，将当前应用的整体目标纳入合并症负担和年龄。该应用程序的总体目标是将几个公开可用的数据文件链接起来，并在美国人口的全国代表性样本中追求以下特定目标：1）确定与影响老年人的某些慢性条件相关的最普遍的合并症； 2）评估慢性条件，合并症相互作用和年龄对影响老年人的慢性疾病的基于偏好的HRQL评分的影响和3）在美国发展慢性ICD-9代码的偏好权重

项目成果

The impact of co-morbidity burden on preference-based health-related quality of life in the United States.

在美国，共病负担对基于偏好的健康相关生活质量的影响。

• DOI: 10.2165/11586840-000000000-00000
• 发表时间: 2012
• 期刊: PharmacoEconomics
• 影响因子: 4.4
• 作者: Sullivan,PatrickW;Ghushchyan,VahramH;Bayliss,ElizabethA
• 通讯作者: Bayliss,ElizabethA