HRQL Impact of Chronic Conditions and Comorbidity Burden

慢性病和合并症负担的 HRQL 影响

• 批准号: 7016561
• 负责人: PATRICK W SULLIVAN
• 金额: $ 6.93万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-15 至 2008-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7016561
• 关键词: aging; behavioral /social science research tag; chronic disease /disorder; comorbidity; cost effectiveness; data collection methodology /evaluation; health care cost /financing; health care service evaluation; health care service planning; health economics; health services research tag; health surveys; human data; psychometrics; quality of life; statistics /biometry

DESCRIPTION (provided by applicant): As life expectancy has increased for the average American, attention is focused on improving health-related quality of life (HRQL). The burgeoning cost of medical care within the reality of limited societal resources has necessitated the use of cost-effectiveness methods to assess the value of competing health interventions for an aging population. Quality-adjusted life years (QALYs) rely on preference weights to adjust the HRQL of different health states: Preference weights are the cornerstone of the QALY method, and are integral to the appropriate use of cost-effectiveness analysis. The Panel on Cost-Effectiveness in Health and Medicine (PCEHM) has called for a catalogue of "off the shelf preference weights associated with conditions that could be used by health researchers to promote the comparability of cost-effectiveness analyses in the U.S., thereby enabling accurate assessment of the medical interventions with the most value for the treatment of chronic conditions in older populations. Sullivan et al. have developed a preliminary catalogue of preference weights for chronic conditions, incorporating a generic examination of comorbidity burden and age. The overall objective of the current application is to 1) increase the depth of the catalogue for select priority conditions affecting older adults by assessing more specifically the impact of age, chronic disease and comorbidity interactions and 2) increase the breadth of the catalogue by examining EQ-5D index scores associated with an additional 293 chronic ICD-9 codes. We plan to accomplish the overall objective of this application by linking several publicly available data files and pursuing the following specific aims in the resultant nationally representative sample of the U.S. population: 1) determine the most prevalent comorbidities associated with select chronic conditions impacting older adults; 2) assess the impact of chronic conditions, comorbidity interactions and age on preference-based HRQL scores for select chronic conditions impacting older adults and 3) develop preference weights for chronic ICD-9 codes in the U.S.

描述（由申请人提供）：随着美国人平均预期寿命的增加，人们的注意力集中在改善与健康相关的生活质量（HRQL）上。在社会资源有限的情况下，医疗费用不断上涨，因此有必要使用成本效益方法来评估针对老龄化人口的竞争性健康干预措施的价值。质量调整生命年 (QALY) 依靠偏好权重来调整不同健康状态的 HRQL：偏好权重是 QALY 方法的基石，并且是正确使用成本效益分析的组成部分。健康与医学成本效益小组 (PCEHM) 呼吁建立一个“与条件相关的现成偏好权重目录，健康研究人员可以使用这些权重来促进美国成本效益分析的可比性，从而使准确评估对治疗老年人群慢性病最有价值的医疗干预措施 Sullivan 等人制定了慢性病偏好权重的初步目录，其中包括对合并症负担的一般检查和评估。当前应用程序的总体目标是 1) 通过更具体地评估年龄、慢性疾病和合并症相互作用的影响来增加影响老年人的选定优先条件的目录深度，以及 2) 增加目录的广度检查与另外 293 个慢性 ICD-9 代码相关的 EQ-5D 指数评分 我们计划通过链接几个公开可用的数据文件并在最终的全国代表性样本中实现以下具体目标来实现此应用程序的总体目标。美国人口：1) 确定与影响老年人的特定慢性病相关的最普遍的合并症； 2) 评估慢性病、合并症相互作用和年龄对影响老年人的特定慢性病的基于偏好的 HRQL 评分的影响；3) 制定美国慢性病 ICD-9 代码的偏好权重。

项目成果

The impact of co-morbidity burden on preference-based health-related quality of life in the United States.

在美国，共病负担对基于偏好的健康相关生活质量的影响。

• DOI: 10.2165/11586840-000000000-00000
• 发表时间: 2012
• 期刊: PharmacoEconomics
• 影响因子: 4.4
• 作者: Sullivan,PatrickW;Ghushchyan,VahramH;Bayliss,ElizabethA
• 通讯作者: Bayliss,ElizabethA