Pediatric maltreatment-related PTSD: Psychobiology

儿科虐待相关的创伤后应激障碍：心理生物学

• 批准号: 7067198
• 负责人: Michael Damingo De Bellis
• 金额: $ 14.54万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7067198
• 关键词: behavioral /social science research tag; biomarker; brain imaging /visualization /scanning; catecholamines; child abuse; clinical research; cognitive behavior therapy; cortisol; human subject; human therapy evaluation; neuropharmacology; neuropsychological tests; neuropsychology; nuclear magnetic resonance spectroscopy; patient oriented research; pediatrics; posttraumatic stress disorder; psychobiology; psychotherapy; questionnaires; sertraline; sex abuse

DESCRIPTION (provided by applicant): This Midcareer Investigator Award in Patient-Oriented Research (K24) application is in response to program announcement (PA-99-133) "Career Development Awards: Child Abuse and Neglect Research." Pediatric maltreatment-related PTSD is associated with dysregulation of biological stress systems, adverse brain maturation, and medial prefrontal cortical dysfunction. Building on previous work in developmental traumatology, the aim of this K24 is to investigate the psychobiology of effective PTSD treatment for sexually-abused children. The objectives of the career development plan are to: 1) develop expertise in evidence-based psychosocial treatments i.e., cognitive behavioral therapy (CBT) and combined psychopharmacologic interventions for maltreated children with PTSD, 2) further the candidate's knowledge of developmental and cognitive neuroscience emphasizing the integration and translation of brain imaging measurement as it relates to neurodiagnostic assessment and treatment, 3) increase the candidate's practical and empirical knowledge in the conduct and design of relevant clinical trials for treatment development including advanced research design, methodology and statistical aspects of conducting longitudinal studies and clinical trials, and 4) emphasize knowledge dissemination of the translational components of this research by mentoring junior colleagues in child abuse and neglect research. The research plan is linked to an ongoing study using brain imaging to help elucidate neurobiological markers in sexually abused children with PTSD. The objective of the research plan is a CBT treatment study using non-invasive biological markers (24 hour urinary concentrations of cortisol and catecholamines, MRS-based brain NAA concentrations of medial prefrontal cortex, and measures of neuropsychological functioning), in a pre-post design to investigate the pathogenesis of PTSD in 30 sexually abused children, ages 6 to 12 years. Exploring these biological markers in trauma-focused CBT + Sertraline and CBT + placebo is also proposed.

描述（由申请人提供）：该中期护理研究者授予患者研究（K24）的申请申请响应计划公告（PA-99-133）“职业发展奖：虐待和忽视儿童研究”。小儿虐待相关的PTSD与生物压力系统的失调，不良脑成熟和内侧前额叶皮质功能障碍有关。基于发育创伤学以前的工作，该K24的目的是调查有效虐待儿童PTSD治疗的心理生物学。职业发展计划的目标是：1）在基于证据的心理社会治疗中发展专业知识，即认知行为疗法（CBT）（CBT）（CBT）和对患有PTSD恶心儿童的心理药物干预措施的结合，PTSD，2）候选人对候选人的发展和认知神经的知识，以评估脑部的整合和对脑的整合量的了解，以此对脑的整合性进行衡量，以此对脑的整合性进行介绍，并将其视为脑图的整合量表。 3）在相关临床试验的行为和设计中，增加了候选人的实践和经验知识，包括进行纵向研究和临床试验的先进研究设计，方法论和统计方面，以及4）强调通过在儿童虐待和忽略研究中指导Junior的研究，强调这项研究的翻译成分的知识传播。该研究计划与正在进行的研究使用脑成像的研究有关，以帮助阐明患有PTSD的性虐待儿童中的神经生物学标志物。该研究计划的目的是使用非侵入性生物学标志物（皮质醇和儿茶酚胺的24小时尿液浓度，基于MRS MRS的脑NAA脑内侧前额叶皮质的浓度以及神经心理功能的度量）的CBT治疗研究，在30岁儿童中，在30年的儿童中，PTSSD的病原体在PTSSD中，Ages Absed Absed Absed Absecs 6，Ages 6岁。还提出了以创伤为重点的CBT +舍曲林和CBT +安慰剂中的这些生物学标记。