Prenatal Influences on Brain and Behavioral Development

产前对大脑和行为发育的影响

• 批准号: 7055448
• 负责人: SARAH J SHORT
• 金额: $ 3.3万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7055448
• 关键词: Macaca mulatta; behavior disorders; behavioral /social science research tag; biomarker; brain imaging /visualization /scanning; cortisol; developmental neurobiology; disease /disorder model; disease /disorder proneness /risk; endocrine disorder; hippocampus; host organism interaction; hypothalamic pituitary adrenal axis; immune response; influenza; magnetic resonance imaging; mental health epidemiology; model design /development; placenta; predoctoral investigator; vertical transmission

DESCRIPTION (provided by applicant): The effects of maternal influenza exposure on the developing fetal brain and the associated risk for behavioral and hormone dysfunction will be examined. The importance of virus-induced changes in maternal immunity and placental physiology will be analyzed with respect to the development of the infant postpartum. The studies proposed for this fellowship are designed to: 1) create a nonhuman primate model of flu infection during pregnancy; 2) identify the physical, behavioral, and neuroendocrine profiles of flu-exposed and control infants; 3) measure hippocampal vulnerability to prenatal insult using structural MR imaging and assessment of the HPA axis in cortisol release and negative feedback. Development of a nonhuman primate model that utilizes a human derived strain of the influenza virus has important implications for understanding how flu exposure during pregnancy may impact the mental and physical health of children. Furthermore, these findings are relevant to neuropsychiatric diseases and cognitive disorders that may be due to disturbed prenatal development, involving high levels of maternal cytokines or steroid hormones that interrupt normal neuronal differentiation and development of the brain

描述（由申请人提供）：将检查母体流感暴露对发育中的胎儿大脑的影响以及行为和激素功能障碍的相关风险。病毒引起的孕产妇免疫变化和胎盘生理学变化的重要性将在婴儿产后的发展方面进行分析。该研究金提出的研究旨在：1）在怀孕期间创建一种非人类灵长类动物的流感感染模型； 2）确定流感暴露和对照婴儿的身体，行为和神经内分泌特征； 3）测量使用结构MR成像和评估皮质醇释放和负反馈中HPA轴的结构MR成像和评估的海马脆弱性。利用人类衍生的流感病毒菌株的非人类灵长类动物模型的开发对于了解怀孕期间的流感暴露会如何影响儿童的心理和身体健康具有重要意义。此外，这些发现与神经精神疾病和认知疾病有关，可能是由于产前发育受到干扰引起的，涉及中断正常神经元分化和大脑发育的高水平的母体细胞因子或类固醇激素