Prenatal Influences on Brain and Behavioral Development

产前对大脑和行为发育的影响

基本信息

批准号：
7454113
负责人：
SARAH J SHORT
金额：
$ 3.78万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-01-01 至 2008-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7454113
关键词：
Age Age-Months Age-Years Animals Antibody Formation Behavior assessment Behavioral Birth Weight Blood Circulation Brain Brain region Breeding Child Development Child health care Circadian Rhythms Classification Cognition Disorders Development Developmental Disabilities Disease Doctor of Philosophy Emotional Epidemiologic Studies Etiology Evaluation Exhibits Exposure to Feedback Fellowship Female Functional disorder Global Change Growth HPSE gene Hippocampus (Brain)Hormones Human Hydrocortisone Image Immune Immunity Individual Infant Infant Behavior Infant Development Infection Influenza Interferon Type II Interleukin-6 Invasive Laboratories Learning Disabilities Length Link Macaca mulatta Magnetic Resonance Imaging Measurement Measures Mental disorders Modeling Monkeys Mothers Names Neonatal Neopterin Neuronal Differentiation Neurosciences Neurosecretory Systems Nose Numbers Patient currently pregnant Peer Group Phase Physiologic pulse Physiology Positioning Attribute Postpartum Period Pregnancy Primates Psyche structure Psychopathology Pulse taking Reaction Research Resolution Risk Rodent Model Scanning Schizophrenia Sensory Process Social Behavior Staging Testing Time Training Ventricular Viral Virus Virus Diseases Virus Shedding Weaning Week behavior observation career cytokine design dexamethasone suppression test emotional reaction fetal flu hypothalamic-pituitary-adrenal axis in utero influenza virus strain interest neural circuit neurochemistry neuroimaging neuropsychiatry nonhuman primate postnatal pre-doctoral prenatal prenatal influence response size social group steroid hormone

项目摘要

DESCRIPTION (provided by applicant): The effects of maternal influenza exposure on the developing fetal brain and the associated risk for behavioral and hormone dysfunction will be examined. The importance of virus-induced changes in maternal immunity and placental physiology will be analyzed with respect to the development of the infant postpartum. The studies proposed for this fellowship are designed to: 1) create a nonhuman primate model of flu infection during pregnancy; 2) identify the physical, behavioral, and neuroendocrine profiles of flu-exposed and control infants; 3) measure hippocampal vulnerability to prenatal insult using structural MR imaging and assessment of the HPA axis in cortisol release and negative feedback. Development of a nonhuman primate model that utilizes a human derived strain of the influenza virus has important implications for understanding how flu exposure during pregnancy may impact the mental and physical health of children. Furthermore, these findings are relevant to neuropsychiatric diseases and cognitive disorders that may be due to disturbed prenatal development, involving high levels of maternal cytokines or steroid hormones that interrupt normal neuronal differentiation and development of the brain

描述（由申请人提供）：将检查母体流感暴露对发育中的胎儿大脑的影响以及行为和激素功能障碍的相关风险。病毒引起的孕产妇免疫变化和胎盘生理学变化的重要性将在婴儿产后的发展方面进行分析。该研究金提出的研究旨在：1）在怀孕期间创建一种非人类灵长类动物的流感感染模型； 2）确定流感暴露和对照婴儿的身体，行为和神经内分泌特征； 3）测量使用结构MR成像和评估皮质醇释放和负反馈中HPA轴的结构MR成像和评估的海马脆弱性。利用人类衍生的流感病毒菌株的非人类灵长类动物模型的开发对于了解怀孕期间的流感暴露会如何影响儿童的心理和身体健康具有重要意义。此外，这些发现与神经精神疾病和认知疾病有关，可能是由于产前发育受到干扰引起的，涉及中断正常神经元分化和大脑发育的高水平的母体细胞因子或类固醇激素