Frontal function in Adolescent Cannabis Use Disorders

青少年大麻使用障碍的额叶功能

基本信息

批准号：
7456491
负责人：
Michael Damingo De Bellis
金额：
$ 45.68万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-09-25 至 2010-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7456491
关键词：
Adolescence Adolescent Adult Age Age of Onset Alcohol abuse Amygdaloid structure Area Attention Attention deficit hyperactivity disorder Basal Ganglia Behavioral Brain Brain imaging Brain region Cannabis Cerebellum Cerebrum Child Child Abuse and Neglect Childhood Clinic Clinical Cognitive Collaborations Communities Conduct Disorder Consumption Control Groups Corpus Callosum DSM-IV Decision Making Development Diagnosis Disease Disease remission Drug abuse Evaluation Female Functional Magnetic Resonance Imaging Functional disorder Funding Gender Gray unit of radiation dose Handedness Hippocampus (Brain)Household Human Image Analysis Incidence Individual Investigation Knowledge Learning MRI Scans Magnetic Resonance Imaging Major Depressive Disorder Marijuana Marijuana Dependence Matched Group Measures Mediating Memory Mental Health Mental disorders Mentally Ill Persons Morbidity - disease rate Neurobiology Nicotine Dependence Numbers Outpatients Pharmaceutical Preparations Play Post-Traumatic Stress Disorders Prefrontal Cortex Principal Investigator Public Health Race Range Rate Recording of previous events Research Research Personnel Respondent Rewards Risk Risk Factors Role Sampling Severities Short-Term Memory Structure Substance Use Disorder Surveys System Testing Time Trauma Traumatology Youth adolescent substance use aged alcohol exposure alcohol use disorder cannabinoid receptor cognitive function design executive function follow-up male morphometry neuropsychological neurotoxicity novel programs prospective psychosocial response sex underage drinking white matter young adult

项目摘要

DESCRIPTION (provided by applicant): In response to RFA-DA-05-007, we propose a 5-year cross sectional investigation with a one-year prospective follow-up to further our understanding of the neurobiological consequences of an adolescent onset cannabis use disorders (CUD; defined as DSM-IV cannabis dependence or abuse) on adolescent prefrontal and hippocampal structural and functional development. We propose to measure prefrontal and hippocampal cognitive function with a comprehensive neuropsychological battery and a functional MRI (fMRI) scan aimed at measuring subdivisions of prefrontal cortex (RFC) involved in decision-making and reward. We hypothesize that adolescent CUD will be associated with deficits of prefrontal and hippocampal function. Three adolescent groups will be compared: 1) adolescents with CUD, who do not have other comorbid substance use disorders (SUDs) and who are entering intensive substance treatment, 2) a high risk for SUD group of adolescents with mental disorders who do not have any SUDs and are age, sex, and sociodemographically matched to the CUD subjects, and 3) age, sex, and sociodemographically matched healthy community control adolescents. Specific aims are to compare measures of prefrontal and hippocampal structure and function in adolescents with CUD at baseline and prefrontal and hippocampal neuropsychological function at baseline, and 6 and 12 month follow-ups. At baseline, a well characterized subsample will undergo a novel fMRI task to measure RFC activity. We will explore the relationship between baseline measures of RFC activity in all adolescent groups to examine factors associated with: 1) nonremission or progression to other SUDs in the adolescent CUD group; and 2) emergence of an adolescent onset CUD in the high risk and healthy control groups; at 6 and 12 months. We will explore clinical summary variable measures of the subject's remission of cannabis use (age of onset of remission, duration of remission) and presence of mental health co-morbidity to try to identify the best clinical predictors of neuropsychological function (e.g. improvement) at 6 and 12 months. The adolescent brain is more vulnerable to the effects of drug abuse than the adult brain. This proposal has public health significance because we will comprehensively evaluate the effects of marijuana on adolescent brain and cognitive development, an understudied area.

描述（由申请人提供）：为了回应 RFA-DA-05-007，我们提议进行一项为期 5 年的横断面调查和一年的前瞻性随访，以进一步了解青少年发作的大麻使用障碍（CUD；定义为 DSM）的神经生物学后果-IV 大麻依赖或滥用）对青少年前额叶和海马结构和功能发育的影响。我们建议通过综合神经心理学电池和功能性核磁共振（fMRI）扫描来测量前额叶和海马认知功能，旨在测量参与决策和奖励的前额叶皮层（RFC）的细分。我们假设青少年 CUD 与前额叶和海马功能缺陷有关。将比较三个青少年群体：1) 患有 CUD 的青少年，他们没有其他共病物质使用障碍 (SUD)，并且正在接受强化物质治疗；2) 患有 SUD 的高风险群体，即患有精神障碍但没有其他共存物质使用障碍 (SUD) 的青少年。任何 SUD 且其年龄、性别和社会人口统计学与 CUD 受试者相匹配，以及 3) 年龄、性别和社会人口统计学相匹配的健康社区对照青少年。具体目的是比较 CUD 青少年基线前额叶和海马结构和功能以及基线以及 6 个月和 12 个月随访时前额叶和海马神经心理功能的测量结果。在基线时，经过良好表征的子样本将接受一项新颖的功能磁共振成像任务来测量 RFC 活动。我们将探讨所有青少年组中 RFC 活动基线测量之间的关系，以检查与以下相关的因素：1）青少年 CUD 组中未缓解或进展为其他 SUD； 2) 在高风险组和健康对照组中出现青少年发病的 CUD； 6 个月和 12 个月时。我们将探索受试者大麻使用缓解的临床总结变量测量（缓解开始年龄、缓解持续时间）和心理健康共病的存在，以试图确定 6 岁时神经心理功能（例如改善）的最佳临床预测因子。和12个月。青少年的大脑比成人的大脑更容易受到药物滥用的影响。该提案具有公共卫生意义，因为我们将全面评估大麻对青少年大脑和认知发展（尚待研究的领域）的影响。