RESPONSIVITY OF HOMOCYSTEINE TO BEHAVIORAL STRESS

同型半胱氨酸对行为压力的反应

• 批准号: 7374577
• 负责人: CHARLES FISKE EMERY
• 金额: $ 2.93万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7374577
• 关键词: RESPONSIVITY; HOMOCYSTEINE; BEHAVIORAL; STRESS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Primary Question and Response Variable: 1.To investigate the significance of stress-related homocysteine changes in the etiology of CHD. (Study 1)To accomplish this aim, we plan to compare homocysteine (Hcy) concentrations during stress in high- and low-risk individuals. Our previous data demonstrated that Hcy concentrations rose significantly and transiently during psychological stress in a small sample of middle-aged women. Our previous data also indicated that healthy men and women high in hostility had higher Hcy concentrations at rest that did those low in hostility. 2.To test a mechanism for the stress-associated homocysteine increases. (Study 2)To accomplish this goal, we will determine if one mechanism for the short-term rise in Hcy during stress is an acute decline in vitamin B6, vitamin B12, and/or folate. Chronic stress results in B6 deficiency, and similar deficiencies within the normal ranges induce negative affective states such as irritability and depression. B6 is an essential cofactor in the trassulfuration of Hcy to cystine, and chronic alterations in these B vitamins are the most important determinants of Hcy. 3.To examine the relationship between stress-induced changes in homocysteine and lipoproteins. (Studies 1 & 2) We have a long-standing interest in understanding the patterns and mechanisms of lipoprotein reactivity to psychological stressors. Because Hcy is bound to lipoproteins, and because it appears to modify the atherogenicity of LDL, we will test the relationships between Hcy and lipid reactivity.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。主要问题和响应变量：1。研究冠心病病因中与压力相关的同型半胱氨酸变化的重要性。 （研究1）为了实现这一目标，我们计划比较高风险个体和低风险个体的压力期间同型半胱氨酸（HCY）的浓度。我们以前的数据表明，在一小部分中年妇女样本中，在心理压力期间，HCY浓度显着增加。我们以前的数据还表明，敌对敌对的健康男人和女性的静止浓度较高，而敌对态度低。 2.测试一种与压力相关的同型半胱氨酸增加的机制。 （研究2）为了实现这一目标，我们将确定压力期间HCY短期上升的一种机制是否是维生素B6，维生素B12和/或叶酸的急性下降。慢性应激会导致B6缺乏症，并且正常范围内类似的缺陷会引起负面情感状态，例如烦躁和抑郁。 B6是HCY胞抑素层硫化的必不可少的辅助因子，这些B族维生素的慢性改变是HCY最重要的决定因素。 3.检查胁迫诱导的同型半胱氨酸和脂蛋白的变化之间的关系。 （研究1和2）我们对理解脂蛋白对心理压力源的反应性的模式和机制具有长期的兴趣。由于HCY与脂蛋白注定，并且由于它似乎会改变LDL的动脉粥样硬化性，因此我们将测试HCY和脂质反应性之间的关系。