PET Detector for Cardiac Imaging of Small Animals

用于小动物心脏成像的 PET 探测器

• 批准号: 7051079
• 负责人: KANAI SHAH
• 金额: $ 12.4万
• 依托单位: RADIATION MONITORING DEVICES, INC.
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7051079
• 关键词: Rodentias; bioimaging /biomedical imaging; biomedical equipment development; cadmium; computed axial tomography; computer simulation; gamma radiation; heart imaging /visualization /scanning; image enhancement; magnetic resonance imaging; positron emission tomography; radiation detector; tellurium

DESCRIPTION (provided by applicant): Positron emission tomography (PET) of small animals is emerging as a very powerful tool for advancing our understanding of human diseases such as heart disease and cancer. Due to the small (sub-millimeter) feature sizes, dedicated, high resolution PET systems are required to obtain sufficiently detailed images of organs of interest. In particular, sub-millimeter spatial resolution is required for detailed, functional heart imaging of mice. Currently, the detectors for most PET systems are based on arrays of dense scintillators (i.e. indirect detectors). Simulations have shown that the pitch of the scintillator arrays is the dominant factor limiting spatial resolution. However, fabricating and accurately decoding scintillators with element size much smaller than 1-mm is very challenging. In addition, as the scintillator element size decreases, the light collection decreases and consequently the energy and timing resolution of the system decreases. Therefore there is a need for an alternative approach for developing an improved detector for small animal PET imaging. The main objective of the Phase I research is to demonstrate the feasibility of producing very high- resolution PET detectors for small animal imaging using a direct detection approach with room temperature CdTe and CZT detectors. The overall detector design that we plan to use in the proposed effort is expected to satisfy all major requirements for small animal imaging including very high spatial resolution, reasonably high sensitivity, and good timing and DOI resolution. Excellent energy resolution can also be expected from the proposed design. The proposed effort is expected to have a lasting value both in terms of its research potential as well as its commercial scope. The most direct application addressed here is that of small animal PET imaging which is showing enormous promise for increasing our understanding of human disease models. Other selected human high-resolution PET applications for breast, brain and pediatric imaging are also emerging where this technology would be applicable. The proposed technology can also play a role in combined PET/CT and PET/MRI imaging instruments under development.

描述（由申请人提供）：小动物的正电子发射断层扫描（PET）正在成为一种非常有力的工具，可以促进我们对人类疾病（例如心脏病和癌症）的理解。由于小（亚毫米）的特征大小，需要专用的高分辨率宠物系统才能获得足够详细的感兴趣器官图像。特别是，需要详细的小鼠功能性心脏成像需要亚毫米空间分辨率。当前，大多数宠物系统的探测器基于密集闪烁的阵列（即间接检测器）。仿真表明，闪烁体阵列的音高是限制空间分辨率的主要因素。但是，制造并准确地解码元素大小小于1毫米的闪光灯非常具有挑战性。另外，随着闪烁体元件尺寸的减小，光收集减小，因此系统的能量和时机分辨率降低。因此，需要采用另一种方法来开发改进的小动物宠物成像的检测器。第一阶段研究的主要目的是证明使用室温CDTE和CZT探测器的直接检测方法生产非常高的分辨率宠物探测器，用于小动物成像。我们计划在拟议的工作中使用的总体检测器设计将满足小动物成像的所有主要要求，包括很高的空间分辨率，相当高的灵敏度以及良好的时机和DOI分辨率。从提议的设计中也可以预期出色的能源分辨率。预计拟议的努力在其研究潜力及其商业范围方面都具有持久的价值。这里解决的最直接应用是小型动物宠物成像的应用，这表明我们对我们对人类疾病模型的理解的巨大希望。其他选择的人类高分辨率宠物应用于乳房，大脑和小儿成像也正在出现在适用该技术的地方。提出的技术还可以在开发的PET/CT和PET/MRI成像仪器中发挥作用。