Ultra-Fast, Effecient Scintilator for PET

用于 PET 的超快速、高效闪烁器

• 批准号: 6776937
• 负责人: KANAI SHAH
• 金额: $ 10万
• 依托单位: RADIATION MONITORING DEVICES, INC.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-16 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6776937
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; chemical synthesis; iodine; lead; positron emission tomography; scintillation cameras

DESCRIPTION (provided by applicant): Positron Emission Tomography (PET) is a nuclear imaging technology that makes use of a range of positron-labeled tracers to provide images that reflect different parameters relevant to tumor biology. PET technology is now playing a prominent and an increasingly visible role in modern cancer research and clinical diagnosis. However, there is urgent need for improvement in PET instrumentation in order to exploit the full potential of this promising technique. The performance of current PET systems is limited by the available detector technology. Scintillation crystals coupled to photomultiplier tubes are commonly used as detectors in PET systems. Important requirements for the scintillation crystals used in PET systems include fast response, high sensitivity, high light output, high energy and timing resolution, and low cost. None of the established scintillators meet all these requirements. The goal of the proposed project is to explore a new scintillator that has the potential to provide ultra-fast response, high gamma ray stopping efficiency, and very high light output. Successful completion of the proposed effort would create exceptional opportunities for PET imaging including time-of-flight PET studies. Commercial Potential: PET, SPECT, CT, radiology, high energy and nuclear physics, X-ray diffraction, Non-destructive evaluation, nuclear non-proliferation, and geological exploration.

描述（由申请人提供）： 正电子发射断层扫描 (PET) 是一种核成像技术，利用一系列正电子标记的示踪剂来提供反映与肿瘤生物学相关的不同参数的图像。 PET技术目前在现代癌症研究和临床诊断中发挥着越来越突出的作用。然而，迫切需要改进 PET 仪器，以便充分发挥这项有前途的技术的潜力。当前 PET 系统的性能受到可用检测器技术的限制。与光电倍增管耦合的闪烁晶体通常用作 PET 系统中的探测器。 PET 系统中使用的闪烁晶体的重要要求包括快速响应、高灵敏度、高光输出、高能量和时间分辨率以及低成本。现有的闪烁体均无法满足所有这些要求。该项目的目标是探索一种新型闪烁体，它有可能提供超快响应、高伽马射线阻止效率和非常高的光输出。成功完成拟议工作将为 PET 成像（包括飞行时间 PET 研究）创造绝佳的机会。商业潜力：PET、SPECT、CT、放射学、高能和核物理、X 射线衍射、无损评估、核不扩散和地质勘探。