Evidence-based Principles of Treatment

循证治疗原则

• 批准号: 7076905
• 负责人: FRANK S PEARSON
• 金额: $ 43.71万
• 依托单位: NATIONAL DEVELOPMENT AND RESEARCH INSTITUTES, INC.
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-10 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7076905
• 关键词: age difference; alcoholism /alcohol abuse information system; clinical research; data collection methodology /evaluation; data management; data quality /integrity; drug abuse therapy; gender difference; human data; human therapy evaluation; meta analysis; outpatient care; rehabilitation; relapse /recurrence; residential care facility

DESCRIPTION (provided by applicant): NIDA has identified principles of effective treatment for substance abusers and the "Andrews Group" has identified principles of effective rehabilitative correctional treatment. Although there are individual studies to support the principles identified by NIDA for substance abusers and there are meta-analytic studies by the Andrews group on corrections-based treatment, no systematic review or meta-analysis of the full research literature has been conducted to verify principles of effective treatment for substance abusers. In previous studies, the research teams from NDRI and ISAP developed two meta-analytic databases containing hundreds of primary research studies of treatment for substance abusers, and these databases contain variables that can be used to test nine of the principles of treatment: six of the thirteen NIDA principles and all three of the Andrews group's principles. The primary aim of this study is to conduct a methodologically strong test of these nine principles. The method employed is systematic reviews and meta-analyses of the existing NDRI and ISAP meta-analytic databases, expanded to include recent studies to be collected for this project. An estimated total of 700 studies of treatment effectiveness will be available for meta-analyses. A secondary aim is to strengthen meta-analytic techniques and improve the methodological quality by (a) identifying sources of inconsistencies in meta-analyses conducted on the same topic and recommending improved protocols, (b) adapting and validating improved measures of the methodological quality of primary research studies, and (c) evaluating the use of different methods for dealing with missing data. The project has implications for practice as it will provide researchers and practitioners substantially more knowledge of (1) which principles of treatment are indeed effective in improving client outcomes, possibly under specific moderating factors (e.g., with specific types of clients), and (2) the scientific strength and limitations of meta-analysis using current protocols and how this essential method can be improved.

描述（由申请人提供）： NIDA 确定了药物滥用者有效治疗的原则，“安德鲁斯小组”确定了有效康复矫正治疗的原则。尽管有个别研究支持 NIDA 为药物滥用者确定的原则，并且安德鲁斯小组也有关于基于矫正的治疗的荟萃分析研究，但尚未对完整的研究文献进行系统回顾或荟萃分析来验证原则药物滥用者的有效治疗。在之前的研究中，NDRI 和 ISAP 的研究团队开发了两个荟萃分析数据库，其中包含数百项药物滥用者治疗的初步研究，这些数据库包含可用于测试九项治疗原则的变量：其中六项NIDA 的 13 项原则和 Andrews 小组的全部 3 项原则。本研究的主要目的是对这九项原则进行方法论上的强有力的测试。所采用的方法是对现有 NDRI 和 ISAP 荟萃分析数据库的系统回顾和荟萃分析，并扩展到包括为本项目收集的最新研究。估计总共有 700 项治疗效果研究可用于荟萃分析。第二个目标是通过以下方式加强荟萃分析技术并提高方法学质量：(a) 确定针对同一主题进行的荟萃分析中不一致的来源并推荐改进的方案；(b) 采用和验证改进的方法学质量衡量标准初步研究，以及 (c) 评估处理缺失数据的不同方法的使用。该项目对实践具有影响，因为它将为研究人员和从业者提供更多关于以下方面的知识：（1）哪些治疗原则确实可以有效地改善客户的结果，可能在特定的调节因素下（例如，针对特定类型的客户），以及（2 ）使用当前协议进行荟萃分析的科学优势和局限性以及如何改进这一基本方法。