DEGRADATION OF CORTICAL FUNCTION IN SENESCENT MONKEYS

衰老猴皮质功能的退化

• 批准号: 7240139
• 负责人: Audie Leventhal
• 金额: $ 5万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-01-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7240139
• 关键词: Macaca mulatta; age difference; animal old age; behavioral /social science research tag; brain electrical activity; brain mapping; cytochrome oxidase; developmental neurobiology; direct cortical response; electrophysiology; immunocytochemistry; lateral geniculate body; morphometry; neuroanatomy; neurophysiology; retinal ganglion; visual cortex; visual perception; visual stimulus

DESCRIPTION (Adapted from Applicant's abstract): Human visual function declines with age. Much of this decline is associated with neuronal changes in the central visual pathways. The purpose of this proposal is, for the first time A highly experienced, productive, and innovative investigator proposes to determine what changes in the visual system account for age-related declines in visual performance. The central hypothesis is that the most relevant alterations in the system occur in visual cortex rather than in the eye, retina, or LGN. Impressive preliminary results from aged and young monkeys support that contention. An array of related experiments are now proposed to evaluate possible changes in the properties of neurons in primary visual cortex, and possible changes in neurotransmitter expression in cortex, and relate these findings to visual behavior in the same monkeys, as well as to possible alternations in the LGN and eye.

描述（改编自申请人的摘要）：人类视觉功能随着年龄的增长而下降。这种下降的大部分与神经元变化有关 中央视觉途径。该提议的目的是首次 经验丰富，富有成效和创新的研究者建议 确定视觉系统中的变化是与年龄相关的下降的原因 视觉性能。中心假设是最相关的 系统中的改变发生在视觉皮层而不是眼中， 视网膜或LGN。年迈和年轻猴子的令人印象深刻的初步结果 支持这一争论。现在提出了一系列相关实验 评估主要视觉中神经元特性的可能变化 皮质，以及皮质中神经递质表达的可能变化，以及 将这些发现与同一猴子中的视觉行为相关联 LGN和眼睛中可能的交替。

项目成果

Degradation of signal timing in cortical areas V1 and V2 of senescent monkeys.

• DOI: 10.1093/cercor/bhh143
• 发表时间: 2005-04
• 期刊: Cerebral cortex
• 影响因子: 3.7
• 作者: Yongchang Wang;Yifeng Zhou;Yuanye Ma;A. Leventhal

The effects of aging on the strength of surround suppression of receptive field of V1 cells in monkeys.

• DOI: 10.1016/j.neuroscience.2010.05.015
• 发表时间: 2010-08-25
• 期刊: NEUROSCIENCE
• 影响因子: 3.3
• 作者: Fu, Y.;Wang, X. S.;Wang, Y. C.;Zhang, J.;Liang, Z.;Zhou, Y. F.;Ma, Y. Y.
• 通讯作者: Ma, Y. Y.