MECHANISMS MEDIATING SUBCORTICAL ORIENTATION SENSITIVITY

皮层下方向敏感性的调节机制

• 批准号: 3265873
• 负责人: Audie Leventhal
• 金额: $ 13.38万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-01-01 至 1993-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3265873
• 关键词: Macaca fascicularis; action potentials; brain subcortex; cats; color visions; corpus striatum; dendritic cells; retinal ganglion; visual cortex; visual pathways; visual photosensitivity; Macaca fascicularis; action potentials; brain subcortex; cats; color visions; corpus striatum; dendritic cells; retinal ganglion; visual cortex; visual pathways; visual photosensitivity

DESCRIPTION: (Investigator's abstract): The application's broad, long-term objectives are to increase our understanding of the functional organization of the visual pathways. The aims of Experiment I and II are to study the retinal, cortical, and intrageniculate contributions to the orientation sensitivity of different types of LGNd relay cells in cats and monkeys, respectively. The aim of Experiment III is to alter the distribution of retinal ganglion cell dendritic field orientations in newborn cats and then, in the adult, to study the orientation sensitivity and morphologies of the altered retinal ganglion cells and the LGNd relay cells and cortical cells which subserve them. The aim of Experiment IV is to study the proportion and distribution of orientation sensitive cells in layer 4c beta of monkey striate cortex. The relationship between the orientation biases of layer 4c beta cells and the orientation preferences of the simple and complex cells in the layers above and below them will also be studied. The experiments will be carried out using standard surgical procedures and computer controlled, quantitative procedures for studying the visually evoked responses of single cells in the visual pathways. Cortical inactivation and the simultaneous recording of action potentials and S potentials will be used to infer the relative contributions of cortical afferents, retinal afferents and intrageniculate mechanisms to the responses of LGNd relay cells. HRP histochemistry, DiI fluorescence labeling, and computerized morphometric analyses will be used to study neuronal morphology. Statistical tests designed specifically to analyze our data will be employed. The proposed studies should 1) increase our understanding of the functional organization of the LGNd, 2) elucidate the function of the corticogeniculate projection, 3) clarify the relationship between cortical and subcortical orientation sensitivity, and 4) provide information which will help us to better understand how form and color are encoded in the M and P cell pathways in primates.

描述：（研究者的摘要）：该应用程序广泛， 长期目标是增加我们对功能的理解 视觉途径的组织。 实验I和II的目的是 研究视网膜，皮质和核内引起的贡献 猫和 猴子分别。 实验III的目的是改变 视网膜神经节细胞树突状场的分布 新生猫，然后在成年人中研究方向敏感性 视网膜神经节细胞和LGND继电器改变的形态 细胞和皮质细胞可用。 实验IV的目的是 研究方向敏感细胞的比例和分布 猴子条皮层的4Cβββ。 之间的关系 第4C级β单元和方向偏好的方向偏差 它们上方和下方的简单复杂的单元格将 也可以研究。 实验将使用标准手术程序进行，并 计算机控制的定量程序用于视觉研究 诱发了视觉途径中单细胞的响应。 皮质 灭活和同时记录动作电位和S 电势将用于推断皮质的相对贡献 传入，视网膜传入和对培训的机制 LGND继电器细胞的响应。 HRP组织化学，DII荧光 标签和计算机化形态计量分析将用于研究 神经元形态。 专门设计的统计测试 我们的数据将被使用。 拟议的研究应1）增加我们对功能的理解 LGND的组织，2）阐明 皮质生成投影，3）阐明皮质之间的关系 和皮层下取向的敏感性，以及4）提供信息 将帮助我们更好地了解M中的形式和颜色如何编码 和灵长类动物中的P细胞途径。