DEVELOPING CORTICAL MAGNETIC STIMULATION FOR PEDIATRICS

开发儿科皮质磁刺激

• 批准号: 3084707
• 负责人: SANDRA L HELMERS
• 金额: $ 8.91万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-04-01 至 1997-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3084707
• 关键词: action potentials; adolescence (12-20); biomagnetism measurement; brain disorder diagnosis; brain electronic stimulator; brain mapping; brain subcortex; cerebral palsy; child (0-11); epilepsy; hemispherectomy; human subject; middle childhood (6-11); motor cortex; neurophysiology; rehabilitation; stroke

I have developed a keen interest in the neurophysiology of the central nervous system over the last few years, particularly in pediatrics. This interest arose from my experiences in clinical neurophysiology, both in adults and in pediatrics. Over the last two years I have become interested in motor development and the effect of motor system diseases upon development and outcome of patients. In the next 5 years I would like to investigate the cortical representation of the motor system in the pediatric population, the effect that particular diseases have upon this cortical organization or reorganization, and the effect of rehabilitation on the motor cortex representation. Using cortical magnetic stimulation and mapping the motor cortex of normal children, its cortical representation can be localized. The next step would be to compare the cortical maps of children with motor system diseases and lesions. The types of disease processes I am interested in would include hemispherectomy for epilepsy, stroke, cerebral palsy (cortical), and traumatic quadriplegia (subcortical). By comparing the cortical maps of the patients to our normal subjects, the question of cortical reorganization can be addressed and any differences between cortical and subcortical lesions can be looked at. The effects of different rehabilitative therapies can be evaluated in relation to the differences in the cortical maps and functional outcome of these patients. The use of the cortical mapping by cortical magnetic stimulation may then be useful in guiding treatment. These projects will be undertaken at the Boston Children's Hospital through the neurology department and neurophysiology laboratory. The normal subjects and patients will come from the outpatient clinics. The magnetic stimulation will be performed in the neurophysiology laboratory which has just purchased a magnetic stimulator.

我对中央的神经生理学产生了浓厚的兴趣 在过去的几年中，尤其是在儿科中的神经系统。 这 我的临床神经生理学经验引起了人们的兴趣 成人和儿科。 在过去的两年中，我变得很感兴趣 在运动发育和运动系统疾病对 患者的发展和结果。 在接下来的5年中，我想 研究运动系统的皮质表示 小儿种群，特定疾病对此的影响 皮质组织或重组以及康复的影响 在运动皮层表示上。 使用皮质磁刺激 并映射正常儿童的运动皮层，其皮质 表示可以本地化。 下一步是比较 患有运动系统疾病和病变儿童的皮质图。 这 我感兴趣的疾病过程类型将包括半球切除术 用于癫痫，中风，脑瘫（皮质）和创伤性四肢瘫痪 （皮层）。 通过比较患者的皮质图与我们的 正常受试者，可以解决皮质重组的问题 并且可以看到皮质和皮质下病变之间的任何差异 在。 可以评估不同康复疗法的影响 与皮质图和功能结果的差异有关 这些患者。 用皮质磁性使用皮质映射 然后，刺激可能有助于指导治疗。 这些项目将 通过神经病学在波士顿儿童医院进行 部门和神经生理学实验室。 正常受试者和 患者将来自门诊诊所。 磁刺激 将在神经生理学实验室中进行 购买了磁刺激器。