Cortico-Limbic Development in Adolescence

青春期皮质边缘系统的发育

基本信息

批准号：
7345572
负责人：
ABIGAIL A BAIRD
金额：
$ 2.97万
依托单位：
VASSAR COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-02-10 至 2008-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7345572
关键词：
adolescence (12-20)behavior test brain imaging /visualization /scanning brain morphology clinical research cognition developmental neurobiology developmental psychology frontal lobe /cortex functional magnetic resonance imaging human subject longitudinal human study performance psychopathology temporal lobe /cortex

项目摘要

DESCRIPTION (provided by applicant): The present research is aimed at better understanding the "conversation" between "affective" and "cognitive" processes that initiates in adolescence. Described below are a series of longitudinal studies that will examine the structure and function of a specific neural system in the developing brain. Structural and functional MR, as well as behavioral measures will be applied to this issue. It is the goal of this work to bring convergent imaging technologies to bear on the relation of brain and mind in the developing adolescent. The current project is directed at understanding the development of the functional connectivity between medial temporal lobe structures, and frontal cortex. It is hypothesized that maturation of these reciprocal projections may be associated with increased cognitive ability, as well as significant improvements in affective competencies and emotional regulation. The maturation of these circuits is believed to be essential for the behavioral milestones required for a successful transition from childhood to adulthood. It is additionally hypothesized that specific types of psychopathology may be associated with perturbation of this developmental sequence. There are three phases to the proposed project that serve to mutually inform one another. Structural MR imagining (both high resolution structural imaging and diffusion tensor imaging), functional neuroimaging, and behavioral measures will be collected from a group of adolescent subjects longitudinally during their adolescence. The investigator will examine the relationships among functional anatomy, morphology, and behavioral performance on cognitive and affective challenge paradigms. Through the acquisition of longitudinal data the investigator hopes to establish correlates which typify neurobiological changes associated with this period of development.

描述（由申请人提供）：目前的研究旨在更好地理解青少年启动的“情感”和“认知”过程之间的“对话”。下面描述的是一系列纵向研究，该研究将检查发育中大脑中特定神经系统的结构和功能。结构和功能性MR以及行为度量将应用于此问题。这项工作的目的是将收敛的成像技术带来发展中的大脑和思想的关系。当前的项目旨在了解内侧颞叶结构和额叶皮层之间功能连接的发展。假设这些相互投影的成熟可能与认知能力的提高以及情感能力和情绪调节的重大改善有关。这些电路的成熟被认为对于从童年到成年的成功过渡所需的行为里程碑至关重要。另外，假设特定类型的心理病理学可能与该发育序列的扰动有关。拟议项目有三个阶段，可以互相告知。结构性MR Imaging（高分辨率结构成像和扩散张量成像），功能性神经影像学和行为度量将在青春期期间纵向从一组青少年受试者那里收集。研究者将研究功能解剖学，形态和行为表现之间在认知和情感挑战范式上的关系。通过获取纵向数据，研究者希望建立相关性，这代表与这一发展时期相关的神经生物学变化。