Cortico-Limbic Development in Adolescence

青春期皮质边缘系统的发育

• 批准号: 7024502
• 负责人: ABIGAIL A BAIRD
• 金额: $ 4.26万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-03-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7024502
• 关键词: adolescence (12-20); behavior test; brain imaging /visualization /scanning; brain morphology; clinical research; cognition; developmental neurobiology; developmental psychology; frontal lobe /cortex; functional magnetic resonance imaging; human subject; longitudinal human study; performance; psychopathology; temporal lobe /cortex

DESCRIPTION (provided by applicant): The present research is aimed at better understanding the "conversation" between "affective" and "cognitive" processes that initiates in adolescence. Described below are a series of longitudinal studies that will examine the structure and function of a specific neural system in the developing brain. Structural and functional MR, as well as behavioral measures will be applied to this issue. It is the goal of this work to bring convergent imaging technologies to bear on the relation of brain and mind in the developing adolescent. The current project is directed at understanding the development of the functional connectivity between medial temporal lobe structures, and frontal cortex. It is hypothesized that maturation of these reciprocal projections may be associated with increased cognitive ability, as well as significant improvements in affective competencies and emotional regulation. The maturation of these circuits is believed to be essential for the behavioral milestones required for a successful transition from childhood to adulthood. It is additionally hypothesized that specific types of psychopathology may be associated with perturbation of this developmental sequence. There are three phases to the proposed project that serve to mutually inform one another. Structural MR imagining (both high resolution structural imaging and diffusion tensor imaging), functional neuroimaging, and behavioral measures will be collected from a group of adolescent subjects longitudinally during their adolescence. The investigator will examine the relationships among functional anatomy, morphology, and behavioral performance on cognitive and affective challenge paradigms. Through the acquisition of longitudinal data the investigator hopes to establish correlates which typify neurobiological changes associated with this period of development.

描述（由申请人提供）：本研究旨在更好地理解青春期开始的“情感”和“认知”过程之间的“对话”。 下面描述的是一系列纵向研究，这些研究将检查发育中大脑中特定神经系统的结构和功能。 结构和功能 MR 以及行为测量将应用于这个问题。 这项工作的目标是利用融合成像技术来影响发育中青少年的大脑和心智的关系。 当前的项目旨在了解内侧颞叶结构和额叶皮层之间功能连接的发展。 据推测，这些相互投射的成熟可能与认知能力的提高以及情感能力和情绪调节的显着改善有关。 这些回路的成熟被认为对于从童年到成年成功过渡所需的行为里程碑至关重要。 另外还假设特定类型的精神病理学可能与这种发育顺序的扰动有关。 拟议项目分为三个阶段，相互通报。 结构磁共振成像（高分辨率结构成像和扩散张量成像）、功能神经成像和行为测量将从一组青少年受试者的青春期纵向收集。 研究者将在认知和情感挑战范式上检查功能解剖学、形态学和行为表现之间的关系。 通过获取纵向数据，研究人员希望建立代表与这一发育时期相关的神经生物学变化的相关性。